Genetic/familial high-risk assessment: Colorectal, version 1.2021 featured updates to the NCCN Guidelines

Jennifer M. Weiss, Samir Gupta, Carol A. Burke, Lisen Axell, Lee May Chen, Daniel C. Chung, Katherine M. Clayback, Susan Dallas, Seth Felder, Olumide Gbolahan, Francis M. Giardiello, William Grady, Michael J. Hall, Heather Hampel, Rachel Hodan, Gregory Idos, Priyanka Kanth, Bryson Katona, Laura Lamps, Xavier LlorPatrick M. Lynch, Arnold J. Markowitz, Sara Pirzadeh-Miller, Niloy Jewel Samadder, David Shibata, Benjamin J. Swanson, Brittany M. Szymaniak, Georgia L. Wiesner, Andrew Wolf, Matthew B. Yurgelun, Mae Zakhour, Susan D. Darlow, Mary A. Dwyer, Mallory Campbell

Research output: Contribution to journalArticlepeer-review

110 Scopus citations


Identifying individuals with hereditary syndromes allows for timely cancer surveillance, opportunities for risk reduction, and syndrome-specific management. Establishing criteria for hereditary cancer risk assessment allows for the identification of individuals who are carriers of pathogenic genetic variants. The NCCN Guidelines for Genetic/Familial High-Risk Assessment: Colorectal provides recommendations for the assessment and management of patients at risk for or diagnosed with high-risk colorectal cancer syndromes. The NCCN Genetic/Familial High-Risk Assessment: Colorectal panel meets annually to evaluate and update their recommendations based on their clinical expertise and new scientific data. These NCCN Guidelines Insights focus on familial adenomatous polyposis (FAP)/attenuated familial adenomatous polyposis (AFAP) syndrome and considerations for management of duodenal neoplasia.

Original languageEnglish
Pages (from-to)1122-1132
Number of pages11
JournalJournal of the National Comprehensive Cancer Network : JNCCN
Issue number10
StatePublished - Oct 2021


  • Adenomatous Polyposis Coli/diagnosis
  • Colorectal Neoplasms/diagnosis
  • Heterozygote
  • Humans
  • Risk Factors


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