Genetic/familial high-risk assessment: Colorectal version 1.2016: Clinical practice guidelines in oncology

Dawn Provenzale; Samir Gupta; Dennis J. Ahnen; Travis Bray; Jamie A. Cannon; Gregory Cooper; Donald S. David; Dayna S. Early; Deborah Erwin; James M. Ford; Francis M. Giardiello; William Grady; Amy L. Halverson; Stanley R. Hamilton; Heather Hampel; Mohammad K. Ismail; Jason B. Klapman; David W. Larson; Audrey J. Lazenby; Patrick M. Lynch; Robert J. Mayer; Reid M. Ness; Scott E. Regenbogen; Niloy Jewel Samadder; Moshe Shike; Gideon Steinbach; David Weinberg; Mary Dwyer; Susan Darlow

doi:10.6004/jnccn.2016.0108

Genetic/familial high-risk assessment: Colorectal version 1.2016: Clinical practice guidelines in oncology

Dawn Provenzale, Samir Gupta, Dennis J. Ahnen, Travis Bray, Jamie A. Cannon, Gregory Cooper, Donald S. David, Dayna S. Early, Deborah Erwin, James M. Ford, Francis M. Giardiello, William Grady, Amy L. Halverson, Stanley R. Hamilton, Heather Hampel, Mohammad K. Ismail, Jason B. Klapman, David W. Larson, Audrey J. Lazenby, Patrick M. LynchRobert J. Mayer, Reid M. Ness, Scott E. Regenbogen, Niloy Jewel Samadder, Moshe Shike, Gideon Steinbach, David Weinberg, Mary Dwyer, Susan Darlow

Research output: Contribution to journal › Article › peer-review

159 Scopus citations

Abstract

This is a focused update highlighting the most current NCCN Guidelines for diagnosis and management of Lynch syndrome. Lynch syndrome is the most common cause of hereditary colorectal cancer, usually resulting from a germline mutation in 1 of 4 DNA mismatch repair genes (MLH1, MSH2, MSH6, or PMS2), or deletions in the EPCAM promoter. Patients with Lynch syndrome are at an increased lifetime risk, compared with the general population, for colorectal cancer, endometrial cancer, and other cancers, including of the stomach and ovary. As of 2016, the panel recommends screening all patients with colorectal cancer for Lynch syndrome and provides recommendations for surveillance for early detection and prevention of Lynch syndrome-associated cancers.

Original language	English
Pages (from-to)	1010-1030
Number of pages	21
Journal	Journal of the National Comprehensive Cancer Network : JNCCN
Volume	14
Issue number	8
DOIs	https://doi.org/10.6004/jnccn.2016.0108
State	Published - Aug 1 2016

Keywords

Colorectal Neoplasms, Hereditary Nonpolyposis/diagnosis
Colorectal Neoplasms/diagnosis
Disease Management
Early Detection of Cancer/methods
Germ-Line Mutation
Humans
Population Surveillance
Risk Assessment

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.6004/jnccn.2016.0108

Cite this

Provenzale, D., Gupta, S., Ahnen, D. J., Bray, T., Cannon, J. A., Cooper, G., David, D. S., Early, D. S., Erwin, D., Ford, J. M., Giardiello, F. M., Grady, W., Halverson, A. L., Hamilton, S. R., Hampel, H., Ismail, M. K., Klapman, J. B., Larson, D. W., Lazenby, A. J., ... Darlow, S. (2016). Genetic/familial high-risk assessment: Colorectal version 1.2016: Clinical practice guidelines in oncology. Journal of the National Comprehensive Cancer Network : JNCCN, 14(8), 1010-1030. https://doi.org/10.6004/jnccn.2016.0108

@article{5ab7c474b4f14601abdbde841cd06b93,

title = "Genetic/familial high-risk assessment: Colorectal version 1.2016: Clinical practice guidelines in oncology",

abstract = "This is a focused update highlighting the most current NCCN Guidelines for diagnosis and management of Lynch syndrome. Lynch syndrome is the most common cause of hereditary colorectal cancer, usually resulting from a germline mutation in 1 of 4 DNA mismatch repair genes (MLH1, MSH2, MSH6, or PMS2), or deletions in the EPCAM promoter. Patients with Lynch syndrome are at an increased lifetime risk, compared with the general population, for colorectal cancer, endometrial cancer, and other cancers, including of the stomach and ovary. As of 2016, the panel recommends screening all patients with colorectal cancer for Lynch syndrome and provides recommendations for surveillance for early detection and prevention of Lynch syndrome-associated cancers.",

keywords = "Colorectal Neoplasms, Hereditary Nonpolyposis/diagnosis, Colorectal Neoplasms/diagnosis, Disease Management, Early Detection of Cancer/methods, Germ-Line Mutation, Humans, Population Surveillance, Risk Assessment",

author = "Dawn Provenzale and Samir Gupta and Ahnen, {Dennis J.} and Travis Bray and Cannon, {Jamie A.} and Gregory Cooper and David, {Donald S.} and Early, {Dayna S.} and Deborah Erwin and Ford, {James M.} and Giardiello, {Francis M.} and William Grady and Halverson, {Amy L.} and Hamilton, {Stanley R.} and Heather Hampel and Ismail, {Mohammad K.} and Klapman, {Jason B.} and Larson, {David W.} and Lazenby, {Audrey J.} and Lynch, {Patrick M.} and Mayer, {Robert J.} and Ness, {Reid M.} and Regenbogen, {Scott E.} and Samadder, {Niloy Jewel} and Moshe Shike and Gideon Steinbach and David Weinberg and Mary Dwyer and Susan Darlow",

note = "Copyright {\textcopyright} 2016 by the National Comprehensive Cancer Network.",

year = "2016",

month = aug,

day = "1",

doi = "10.6004/jnccn.2016.0108",

language = "English",

volume = "14",

pages = "1010--1030",

journal = "Journal of the National Comprehensive Cancer Network : JNCCN",

issn = "1540-1405",

publisher = "Cold Spring Publishing LLC",

number = "8",

}

Provenzale, D, Gupta, S, Ahnen, DJ, Bray, T, Cannon, JA, Cooper, G, David, DS, Early, DS, Erwin, D, Ford, JM, Giardiello, FM, Grady, W, Halverson, AL, Hamilton, SR, Hampel, H, Ismail, MK, Klapman, JB, Larson, DW, Lazenby, AJ, Lynch, PM, Mayer, RJ, Ness, RM, Regenbogen, SE, Samadder, NJ, Shike, M, Steinbach, G, Weinberg, D, Dwyer, M & Darlow, S 2016, 'Genetic/familial high-risk assessment: Colorectal version 1.2016: Clinical practice guidelines in oncology', Journal of the National Comprehensive Cancer Network : JNCCN, vol. 14, no. 8, pp. 1010-1030. https://doi.org/10.6004/jnccn.2016.0108

TY - JOUR

T1 - Genetic/familial high-risk assessment

T2 - Colorectal version 1.2016: Clinical practice guidelines in oncology

AU - Provenzale, Dawn

AU - Gupta, Samir

AU - Ahnen, Dennis J.

AU - Bray, Travis

AU - Cannon, Jamie A.

AU - Cooper, Gregory

AU - David, Donald S.

AU - Early, Dayna S.

AU - Erwin, Deborah

AU - Ford, James M.

AU - Giardiello, Francis M.

AU - Grady, William

AU - Halverson, Amy L.

AU - Hamilton, Stanley R.

AU - Hampel, Heather

AU - Ismail, Mohammad K.

AU - Klapman, Jason B.

AU - Larson, David W.

AU - Lazenby, Audrey J.

AU - Lynch, Patrick M.

AU - Mayer, Robert J.

AU - Ness, Reid M.

AU - Regenbogen, Scott E.

AU - Samadder, Niloy Jewel

AU - Shike, Moshe

AU - Steinbach, Gideon

AU - Weinberg, David

AU - Dwyer, Mary

AU - Darlow, Susan

PY - 2016/8/1

Y1 - 2016/8/1

N2 - This is a focused update highlighting the most current NCCN Guidelines for diagnosis and management of Lynch syndrome. Lynch syndrome is the most common cause of hereditary colorectal cancer, usually resulting from a germline mutation in 1 of 4 DNA mismatch repair genes (MLH1, MSH2, MSH6, or PMS2), or deletions in the EPCAM promoter. Patients with Lynch syndrome are at an increased lifetime risk, compared with the general population, for colorectal cancer, endometrial cancer, and other cancers, including of the stomach and ovary. As of 2016, the panel recommends screening all patients with colorectal cancer for Lynch syndrome and provides recommendations for surveillance for early detection and prevention of Lynch syndrome-associated cancers.

AB - This is a focused update highlighting the most current NCCN Guidelines for diagnosis and management of Lynch syndrome. Lynch syndrome is the most common cause of hereditary colorectal cancer, usually resulting from a germline mutation in 1 of 4 DNA mismatch repair genes (MLH1, MSH2, MSH6, or PMS2), or deletions in the EPCAM promoter. Patients with Lynch syndrome are at an increased lifetime risk, compared with the general population, for colorectal cancer, endometrial cancer, and other cancers, including of the stomach and ovary. As of 2016, the panel recommends screening all patients with colorectal cancer for Lynch syndrome and provides recommendations for surveillance for early detection and prevention of Lynch syndrome-associated cancers.

KW - Colorectal Neoplasms, Hereditary Nonpolyposis/diagnosis

KW - Colorectal Neoplasms/diagnosis

KW - Disease Management

KW - Early Detection of Cancer/methods

KW - Germ-Line Mutation

KW - Humans

KW - Population Surveillance

KW - Risk Assessment

UR - http://www.scopus.com/inward/record.url?scp=84982980766&partnerID=8YFLogxK

U2 - 10.6004/jnccn.2016.0108

DO - 10.6004/jnccn.2016.0108

M3 - Article

C2 - 27496117

AN - SCOPUS:84982980766

SN - 1540-1405

VL - 14

SP - 1010

EP - 1030

JO - Journal of the National Comprehensive Cancer Network : JNCCN

JF - Journal of the National Comprehensive Cancer Network : JNCCN

IS - 8

ER -

Genetic/familial high-risk assessment: Colorectal version 1.2016: Clinical practice guidelines in oncology

Abstract

Keywords

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this