Genetic/familial high-risk assessment: Breast and ovarian, version 2.2015 Featured updates to the NCCN guidelines

Mary B. Daly; Robert Pilarski; Jennifer E. Axilbund; Michael Berry; Saundra S. Buys; Beth Crawford; Meagan Farmer; Susan Friedman; Judy E. Garber; Seema Khan; Catherine Klein; Wendy Kohlmann; Allison Kurian; Jennifer K. Litton; Lisa Madlensky; P. Kelly Marcom; Sofia D. Merajver; Kenneth Offit; Tuya Pal; Huma Rana; Gwen Reiser; Mark E. Robson; Kristen Mahoney Shannon; Elizabeth Swisher; Nicoleta C. Voian; Jeffrey N. Weitzel; Alison Whelan; Myra J. Wick; Georgia L. Wiesner; Mary Dwyer; Rashmi Kumar; Susan Darlow

doi:10.6004/jnccn.2016.0018

Genetic/familial high-risk assessment: Breast and ovarian, version 2.2015 Featured updates to the NCCN guidelines

Mary B. Daly, Robert Pilarski, Jennifer E. Axilbund, Michael Berry, Saundra S. Buys, Beth Crawford, Meagan Farmer, Susan Friedman, Judy E. Garber, Seema Khan, Catherine Klein, Wendy Kohlmann, Allison Kurian, Jennifer K. Litton, Lisa Madlensky, P. Kelly Marcom, Sofia D. Merajver, Kenneth Offit, Tuya Pal, Huma RanaGwen Reiser, Mark E. Robson, Kristen Mahoney Shannon, Elizabeth Swisher, Nicoleta C. Voian, Jeffrey N. Weitzel, Alison Whelan, Myra J. Wick, Georgia L. Wiesner, Mary Dwyer, Rashmi Kumar, Susan Darlow

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Abstract

The NCCN Guidelines for Genetic/Familial High-Risk Assessment: Breast and Ovarian provide recommendations for genetic testing and counseling and risk assessment and management for hereditary cancer syndromes. Guidelines focus on syndromes associated with an increased risk of breast and/or ovarian cancer and are intended to assist with clinical and shared decision-making. These NCCN Guidelines Insights summarize major discussion points of the 2015 NCCN Genetic/Familial High-Risk Assessment: Breast and Ovarian panel meeting. Major discussion topics this year included multigene testing, risk management recommendations for less common genetic mutations, and salpingectomy for ovarian cancer risk reduction. The panel also discussed revisions to genetic testing criteria that take into account ovarian cancer histology and personal history of pancreatic cancer.

Original language	English
Pages (from-to)	153-162
Number of pages	10
Journal	Journal of the National Comprehensive Cancer Network : JNCCN
Volume	14
Issue number	2
DOIs	https://doi.org/10.6004/jnccn.2016.0018
State	Published - Feb 1 2016

Keywords

Breast Neoplasms/genetics
Female
Genetic Counseling/methods
Genetic Predisposition to Disease/genetics
Genetic Testing/methods
Humans
Mutation/genetics
Neoplastic Syndromes, Hereditary/genetics
Ovarian Neoplasms/genetics
Pancreatic Neoplasms/genetics
Risk Assessment/methods
Risk Factors

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10.6004/jnccn.2016.0018

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Daly, M. B., Pilarski, R., Axilbund, J. E., Berry, M., Buys, S. S., Crawford, B., Farmer, M., Friedman, S., Garber, J. E., Khan, S., Klein, C., Kohlmann, W., Kurian, A., Litton, J. K., Madlensky, L., Marcom, P. K., Merajver, S. D., Offit, K., Pal, T., ... Darlow, S. (2016). Genetic/familial high-risk assessment: Breast and ovarian, version 2.2015 Featured updates to the NCCN guidelines. Journal of the National Comprehensive Cancer Network : JNCCN, 14(2), 153-162. https://doi.org/10.6004/jnccn.2016.0018

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title = "Genetic/familial high-risk assessment: Breast and ovarian, version 2.2015 Featured updates to the NCCN guidelines",

abstract = "The NCCN Guidelines for Genetic/Familial High-Risk Assessment: Breast and Ovarian provide recommendations for genetic testing and counseling and risk assessment and management for hereditary cancer syndromes. Guidelines focus on syndromes associated with an increased risk of breast and/or ovarian cancer and are intended to assist with clinical and shared decision-making. These NCCN Guidelines Insights summarize major discussion points of the 2015 NCCN Genetic/Familial High-Risk Assessment: Breast and Ovarian panel meeting. Major discussion topics this year included multigene testing, risk management recommendations for less common genetic mutations, and salpingectomy for ovarian cancer risk reduction. The panel also discussed revisions to genetic testing criteria that take into account ovarian cancer histology and personal history of pancreatic cancer.",

keywords = "Breast Neoplasms/genetics, Female, Genetic Counseling/methods, Genetic Predisposition to Disease/genetics, Genetic Testing/methods, Humans, Mutation/genetics, Neoplastic Syndromes, Hereditary/genetics, Ovarian Neoplasms/genetics, Pancreatic Neoplasms/genetics, Risk Assessment/methods, Risk Factors",

author = "Daly, {Mary B.} and Robert Pilarski and Axilbund, {Jennifer E.} and Michael Berry and Buys, {Saundra S.} and Beth Crawford and Meagan Farmer and Susan Friedman and Garber, {Judy E.} and Seema Khan and Catherine Klein and Wendy Kohlmann and Allison Kurian and Litton, {Jennifer K.} and Lisa Madlensky and Marcom, {P. Kelly} and Merajver, {Sofia D.} and Kenneth Offit and Tuya Pal and Huma Rana and Gwen Reiser and Robson, {Mark E.} and Shannon, {Kristen Mahoney} and Elizabeth Swisher and Voian, {Nicoleta C.} and Weitzel, {Jeffrey N.} and Alison Whelan and Wick, {Myra J.} and Wiesner, {Georgia L.} and Mary Dwyer and Rashmi Kumar and Susan Darlow",

note = "Publisher Copyright: {\textcopyright} 2016 JNCCN-Journal of the National Comprehensive Cancer Network.",

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doi = "10.6004/jnccn.2016.0018",

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Daly, MB, Pilarski, R, Axilbund, JE, Berry, M, Buys, SS, Crawford, B, Farmer, M, Friedman, S, Garber, JE, Khan, S, Klein, C, Kohlmann, W, Kurian, A, Litton, JK, Madlensky, L, Marcom, PK, Merajver, SD, Offit, K, Pal, T, Rana, H, Reiser, G, Robson, ME, Shannon, KM, Swisher, E, Voian, NC, Weitzel, JN, Whelan, A, Wick, MJ, Wiesner, GL, Dwyer, M, Kumar, R & Darlow, S 2016, 'Genetic/familial high-risk assessment: Breast and ovarian, version 2.2015 Featured updates to the NCCN guidelines', Journal of the National Comprehensive Cancer Network : JNCCN, vol. 14, no. 2, pp. 153-162. https://doi.org/10.6004/jnccn.2016.0018

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AU - Pilarski, Robert

AU - Axilbund, Jennifer E.

AU - Berry, Michael

AU - Buys, Saundra S.

AU - Crawford, Beth

AU - Farmer, Meagan

AU - Friedman, Susan

AU - Garber, Judy E.

AU - Khan, Seema

AU - Klein, Catherine

AU - Kohlmann, Wendy

AU - Kurian, Allison

AU - Litton, Jennifer K.

AU - Madlensky, Lisa

AU - Marcom, P. Kelly

AU - Merajver, Sofia D.

AU - Offit, Kenneth

AU - Pal, Tuya

AU - Rana, Huma

AU - Reiser, Gwen

AU - Robson, Mark E.

AU - Shannon, Kristen Mahoney

AU - Swisher, Elizabeth

AU - Voian, Nicoleta C.

AU - Weitzel, Jeffrey N.

AU - Whelan, Alison

AU - Wick, Myra J.

AU - Wiesner, Georgia L.

AU - Dwyer, Mary

AU - Kumar, Rashmi

AU - Darlow, Susan

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KW - Female

KW - Genetic Counseling/methods

KW - Genetic Predisposition to Disease/genetics

KW - Genetic Testing/methods

KW - Humans

KW - Mutation/genetics

KW - Neoplastic Syndromes, Hereditary/genetics

KW - Ovarian Neoplasms/genetics

KW - Pancreatic Neoplasms/genetics

KW - Risk Assessment/methods

KW - Risk Factors

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DO - 10.6004/jnccn.2016.0018

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JO - Journal of the National Comprehensive Cancer Network : JNCCN

JF - Journal of the National Comprehensive Cancer Network : JNCCN

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ER -

Genetic/familial high-risk assessment: Breast and ovarian, version 2.2015 Featured updates to the NCCN guidelines

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Keywords

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