Abstract
Melanoma is a complex disease that exhibits highly heterogeneous etiological, histopathological, and genetic features, as well as therapeutic responses. Genetically engineered mouse (GEM) models provide powerful tools to unravel the molecular mechanisms critical for melanoma development and drug resistance. Here, we expound briefly the basis of the mouse modeling design, the available technology for genetic engineering, and the aspects influencing the use of GEMs to model melanoma. Furthermore, we describe in detail the currently available GEM models of melanoma. Cancer 2017;123:2089-103.
| Original language | English |
|---|---|
| Pages (from-to) | 2089-2103 |
| Number of pages | 15 |
| Journal | Cancer |
| Volume | 123 |
| Issue number | S11 |
| DOIs | |
| State | Published - Jun 1 2017 |
UN SDGs
This output contributes to the following UN Sustainable Development Goals (SDGs)
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SDG 3 Good Health and Well-being
Keywords
- carcinogen
- genetically engineered mice
- melanoma
- mouse models
- ultraviolet (UV) radiation
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