Genetically engineered mouse models of melanoma

Eva Pérez-Guijarro; Chi Ping Day; Glenn Merlino; M. Raza Zaidi

doi:10.1002/cncr.30684

Genetically engineered mouse models of melanoma

Eva Pérez-Guijarro, Chi Ping Day, Glenn Merlino, M. Raza Zaidi

National Institutes of Health

Research output: Contribution to journal › Review article › peer-review

56 Scopus citations

Abstract

Melanoma is a complex disease that exhibits highly heterogeneous etiological, histopathological, and genetic features, as well as therapeutic responses. Genetically engineered mouse (GEM) models provide powerful tools to unravel the molecular mechanisms critical for melanoma development and drug resistance. Here, we expound briefly the basis of the mouse modeling design, the available technology for genetic engineering, and the aspects influencing the use of GEMs to model melanoma. Furthermore, we describe in detail the currently available GEM models of melanoma. Cancer 2017;123:2089-103.

Original language	English
Pages (from-to)	2089-2103
Number of pages	15
Journal	Cancer
Volume	123
DOIs	https://doi.org/10.1002/cncr.30684
State	Published - Jun 1 2017

Keywords

carcinogen
genetically engineered mice
melanoma
mouse models
ultraviolet (UV) radiation

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1002/cncr.30684

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title = "Genetically engineered mouse models of melanoma",

abstract = "Melanoma is a complex disease that exhibits highly heterogeneous etiological, histopathological, and genetic features, as well as therapeutic responses. Genetically engineered mouse (GEM) models provide powerful tools to unravel the molecular mechanisms critical for melanoma development and drug resistance. Here, we expound briefly the basis of the mouse modeling design, the available technology for genetic engineering, and the aspects influencing the use of GEMs to model melanoma. Furthermore, we describe in detail the currently available GEM models of melanoma. Cancer 2017;123:2089-103.",

keywords = "carcinogen, genetically engineered mice, melanoma, mouse models, ultraviolet (UV) radiation",

author = "Eva P{\'e}rez-Guijarro and Day, {Chi Ping} and Glenn Merlino and Zaidi, {M. Raza}",

note = "Publisher Copyright: {\textcopyright} 2017 American Cancer Society",

year = "2017",

month = jun,

day = "1",

doi = "10.1002/cncr.30684",

language = "English",

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T1 - Genetically engineered mouse models of melanoma

AU - Pérez-Guijarro, Eva

AU - Day, Chi Ping

AU - Merlino, Glenn

AU - Zaidi, M. Raza

PY - 2017/6/1

Y1 - 2017/6/1

N2 - Melanoma is a complex disease that exhibits highly heterogeneous etiological, histopathological, and genetic features, as well as therapeutic responses. Genetically engineered mouse (GEM) models provide powerful tools to unravel the molecular mechanisms critical for melanoma development and drug resistance. Here, we expound briefly the basis of the mouse modeling design, the available technology for genetic engineering, and the aspects influencing the use of GEMs to model melanoma. Furthermore, we describe in detail the currently available GEM models of melanoma. Cancer 2017;123:2089-103.

AB - Melanoma is a complex disease that exhibits highly heterogeneous etiological, histopathological, and genetic features, as well as therapeutic responses. Genetically engineered mouse (GEM) models provide powerful tools to unravel the molecular mechanisms critical for melanoma development and drug resistance. Here, we expound briefly the basis of the mouse modeling design, the available technology for genetic engineering, and the aspects influencing the use of GEMs to model melanoma. Furthermore, we describe in detail the currently available GEM models of melanoma. Cancer 2017;123:2089-103.

KW - carcinogen

KW - genetically engineered mice

KW - melanoma

KW - mouse models

KW - ultraviolet (UV) radiation

UR - http://www.scopus.com/inward/record.url?scp=85019838700&partnerID=8YFLogxK

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SN - 0008-543X

VL - 123

SP - 2089

EP - 2103

JO - Cancer

JF - Cancer

ER -

Genetically engineered mouse models of melanoma

Abstract

Keywords

UN SDGs

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