Genetic-susceptibility factor and malignant mesothelioma in the Cappadocian region of Turkey

Iman Roushdy-Hammady; Jennifer Siegel; Salih Emri; Joseph R. Testa; Michele Carbone

doi:10.1016/S0140-6736(00)04013-7

Genetic-susceptibility factor and malignant mesothelioma in the Cappadocian region of Turkey

Iman Roushdy-Hammady, Jennifer Siegel, Salih Emri, Joseph R. Testa, Michele Carbone

Cancer Prevention and Control (CPC)

Research output: Contribution to journal › Article › peer-review

233 Scopus citations

Abstract

Erionite present in stones used to build the villages of Karain and Tuzköy, Turkey, mined from nearby caves, is purported to cause mesothelioma in half of the villagers. We constructed genetic epidemiology maps to test whether some villagers were genetically predisposed to mesothelioma. Analysis of a six-generation extended pedigree of 526 individuals showed that mesothelioma was genetically transmitted, probably in an autosomal dominant way. This finding should lead to preventive strategies to lower the incidence of mesothelioma in future generations, and close monitoring of high-risk individuals might allow early detection and cure.

Original language	English
Pages (from-to)	444-445
Number of pages	2
Journal	Lancet
Volume	357
Issue number	9254
DOIs	https://doi.org/10.1016/S0140-6736(00)04013-7
State	Published - Feb 10 2001

Keywords

Adult
Aged
Chromosome Aberrations/genetics
Chromosome Disorders
Female
Founder Effect
Genes, Dominant/genetics
Genetic Predisposition to Disease/genetics
Genetics, Population
Humans
Inbreeding
Male
Mesothelioma/genetics
Middle Aged
Mining
Pedigree
Pleural Neoplasms/genetics
Survival Rate
Turkey
Zeolites/adverse effects

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10.1016/S0140-6736(00)04013-7

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title = "Genetic-susceptibility factor and malignant mesothelioma in the Cappadocian region of Turkey",

abstract = "Erionite present in stones used to build the villages of Karain and Tuzk{\"o}y, Turkey, mined from nearby caves, is purported to cause mesothelioma in half of the villagers. We constructed genetic epidemiology maps to test whether some villagers were genetically predisposed to mesothelioma. Analysis of a six-generation extended pedigree of 526 individuals showed that mesothelioma was genetically transmitted, probably in an autosomal dominant way. This finding should lead to preventive strategies to lower the incidence of mesothelioma in future generations, and close monitoring of high-risk individuals might allow early detection and cure.",

keywords = "Adult, Aged, Chromosome Aberrations/genetics, Chromosome Disorders, Female, Founder Effect, Genes, Dominant/genetics, Genetic Predisposition to Disease/genetics, Genetics, Population, Humans, Inbreeding, Male, Mesothelioma/genetics, Middle Aged, Mining, Pedigree, Pleural Neoplasms/genetics, Survival Rate, Turkey, Zeolites/adverse effects",

author = "Iman Roushdy-Hammady and Jennifer Siegel and Salih Emri and Testa, {Joseph R.} and Michele Carbone",

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doi = "10.1016/S0140-6736(00)04013-7",

language = "English",

volume = "357",

pages = "444--445",

journal = "Lancet",

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T1 - Genetic-susceptibility factor and malignant mesothelioma in the Cappadocian region of Turkey

AU - Roushdy-Hammady, Iman

AU - Siegel, Jennifer

AU - Emri, Salih

AU - Testa, Joseph R.

AU - Carbone, Michele

PY - 2001/2/10

Y1 - 2001/2/10

N2 - Erionite present in stones used to build the villages of Karain and Tuzköy, Turkey, mined from nearby caves, is purported to cause mesothelioma in half of the villagers. We constructed genetic epidemiology maps to test whether some villagers were genetically predisposed to mesothelioma. Analysis of a six-generation extended pedigree of 526 individuals showed that mesothelioma was genetically transmitted, probably in an autosomal dominant way. This finding should lead to preventive strategies to lower the incidence of mesothelioma in future generations, and close monitoring of high-risk individuals might allow early detection and cure.

AB - Erionite present in stones used to build the villages of Karain and Tuzköy, Turkey, mined from nearby caves, is purported to cause mesothelioma in half of the villagers. We constructed genetic epidemiology maps to test whether some villagers were genetically predisposed to mesothelioma. Analysis of a six-generation extended pedigree of 526 individuals showed that mesothelioma was genetically transmitted, probably in an autosomal dominant way. This finding should lead to preventive strategies to lower the incidence of mesothelioma in future generations, and close monitoring of high-risk individuals might allow early detection and cure.

KW - Adult

KW - Aged

KW - Chromosome Aberrations/genetics

KW - Chromosome Disorders

KW - Female

KW - Founder Effect

KW - Genes, Dominant/genetics

KW - Genetic Predisposition to Disease/genetics

KW - Genetics, Population

KW - Humans

KW - Inbreeding

KW - Male

KW - Mesothelioma/genetics

KW - Middle Aged

KW - Mining

KW - Pedigree

KW - Pleural Neoplasms/genetics

KW - Survival Rate

KW - Turkey

KW - Zeolites/adverse effects

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U2 - 10.1016/S0140-6736(00)04013-7

DO - 10.1016/S0140-6736(00)04013-7

M3 - Article

C2 - 11273069

AN - SCOPUS:0035835437

SN - 0140-6736

VL - 357

SP - 444

EP - 445

JO - Lancet

JF - Lancet

IS - 9254

ER -

Genetic-susceptibility factor and malignant mesothelioma in the Cappadocian region of Turkey

Abstract

Keywords

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