Functional, Morphological, and Evolutionary Characterization of Hearing in Subterranean, Eusocial African Mole-Rats

Sonja J. Pyott; Marcel van Tuinen; Laurel A. Screven; Katrina M. Schrode; Jun Ping Bai; Catherine M. Barone; Steven D. Price; Anna Lysakowski; Maxwell Sanderford; Sudhir Kumar; Joseph Santos-Sacchi; Amanda M. Lauer; Thomas J. Park

doi:10.1016/j.cub.2020.08.035

Functional, Morphological, and Evolutionary Characterization of Hearing in Subterranean, Eusocial African Mole-Rats

Sonja J. Pyott, Marcel van Tuinen, Laurel A. Screven, Katrina M. Schrode, Jun Ping Bai, Catherine M. Barone, Steven D. Price, Anna Lysakowski, Maxwell Sanderford, Sudhir Kumar, Joseph Santos-Sacchi, Amanda M. Lauer, Thomas J. Park

Research output: Contribution to journal › Article › peer-review

17 Scopus citations

Abstract

Pyott et al. attribute comparatively poor hearing in African naked and Damaraland mole-rats to lack of cochlear amplification, disrupted hair bundles, and hair bundle proteins bearing deafness-associated amino acid substitutions. Positive selection in some bundle proteins suggests altered hearing is adaptive to subterranean and eusocial lifestyles.

Original language	English
Pages (from-to)	4329-4341.e4
Journal	Current Biology
Volume	30
Issue number	22
DOIs	https://doi.org/10.1016/j.cub.2020.08.035
State	Published - Nov 16 2020
Externally published	Yes

Keywords

adaptive
auditory outer hair cells
cochlea
cochlear amplifier
deafness
evolution
hair bundle
prestin
selection
stereocilia

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10.1016/j.cub.2020.08.035

Cite this

Pyott, S. J., van Tuinen, M., Screven, L. A., Schrode, K. M., Bai, J. P., Barone, C. M., Price, S. D., Lysakowski, A., Sanderford, M., Kumar, S., Santos-Sacchi, J., Lauer, A. M., & Park, T. J. (2020). Functional, Morphological, and Evolutionary Characterization of Hearing in Subterranean, Eusocial African Mole-Rats. Current Biology, 30(22), 4329-4341.e4. https://doi.org/10.1016/j.cub.2020.08.035

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title = "Functional, Morphological, and Evolutionary Characterization of Hearing in Subterranean, Eusocial African Mole-Rats",

abstract = "Pyott et al. attribute comparatively poor hearing in African naked and Damaraland mole-rats to lack of cochlear amplification, disrupted hair bundles, and hair bundle proteins bearing deafness-associated amino acid substitutions. Positive selection in some bundle proteins suggests altered hearing is adaptive to subterranean and eusocial lifestyles.",

keywords = "adaptive, auditory outer hair cells, cochlea, cochlear amplifier, deafness, evolution, hair bundle, prestin, selection, stereocilia",

author = "Pyott, {Sonja J.} and {van Tuinen}, Marcel and Screven, {Laurel A.} and Schrode, {Katrina M.} and Bai, {Jun Ping} and Barone, {Catherine M.} and Price, {Steven D.} and Anna Lysakowski and Maxwell Sanderford and Sudhir Kumar and Joseph Santos-Sacchi and Lauer, {Amanda M.} and Park, {Thomas J.}",

note = "Publisher Copyright: {\textcopyright} 2020 Elsevier Inc.",

year = "2020",

month = nov,

day = "16",

doi = "10.1016/j.cub.2020.08.035",

language = "English",

volume = "30",

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journal = "Current Biology",

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Pyott, SJ, van Tuinen, M, Screven, LA, Schrode, KM, Bai, JP, Barone, CM, Price, SD, Lysakowski, A, Sanderford, M, Kumar, S, Santos-Sacchi, J, Lauer, AM & Park, TJ 2020, 'Functional, Morphological, and Evolutionary Characterization of Hearing in Subterranean, Eusocial African Mole-Rats', Current Biology, vol. 30, no. 22, pp. 4329-4341.e4. https://doi.org/10.1016/j.cub.2020.08.035

TY - JOUR

T1 - Functional, Morphological, and Evolutionary Characterization of Hearing in Subterranean, Eusocial African Mole-Rats

AU - Pyott, Sonja J.

AU - van Tuinen, Marcel

AU - Screven, Laurel A.

AU - Schrode, Katrina M.

AU - Bai, Jun Ping

AU - Barone, Catherine M.

AU - Price, Steven D.

AU - Lysakowski, Anna

AU - Sanderford, Maxwell

AU - Kumar, Sudhir

AU - Santos-Sacchi, Joseph

AU - Lauer, Amanda M.

AU - Park, Thomas J.

PY - 2020/11/16

Y1 - 2020/11/16

N2 - Pyott et al. attribute comparatively poor hearing in African naked and Damaraland mole-rats to lack of cochlear amplification, disrupted hair bundles, and hair bundle proteins bearing deafness-associated amino acid substitutions. Positive selection in some bundle proteins suggests altered hearing is adaptive to subterranean and eusocial lifestyles.

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KW - adaptive

KW - auditory outer hair cells

KW - cochlea

KW - cochlear amplifier

KW - deafness

KW - evolution

KW - hair bundle

KW - prestin

KW - selection

KW - stereocilia

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DO - 10.1016/j.cub.2020.08.035

M3 - Article

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AN - SCOPUS:85091243891

SN - 0960-9822

VL - 30

SP - 4329-4341.e4

JO - Current Biology

JF - Current Biology

IS - 22

ER -

Functional, Morphological, and Evolutionary Characterization of Hearing in Subterranean, Eusocial African Mole-Rats

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Keywords

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Hearing Loss in Mole-Rats is Adaptive, Beneficial Trait, Research Shows

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Functional, Morphological, and Evolutionary Characterization of Hearing in Subterranean, Eusocial African Mole-Rats

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Hearing Loss in Mole-Rats is Adaptive, Beneficial Trait, Research Shows

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