TY - JOUR
T1 - From UVs to metastases
T2 - Modeling melanoma initiation and progression in the mouse
AU - Zaidi, M. Raza
AU - Day, Chi Ping
AU - Merlino, Glenn
PY - 2008/10
Y1 - 2008/10
N2 - Cutaneous malignant melanoma is highly invasive and capable of metastasizing to distant sites where it is typically resistant to available therapy. While striving to prevent or eradicate melanoma, researchers have two significant advantages not shared by those working on many other cancers. The main environmental etiological agent, UV radiation, is known and melanocytic lesions are excisable for molecular analysis from most stages. Yet knowledge about how UV initiates melanoma has been insufficient to achieve prevention, and the understanding of metastatic mechanisms has been inadequate to reduce mortality. Here, we review the value of melanoma mouse models, focusing on these critical early and late stages.
AB - Cutaneous malignant melanoma is highly invasive and capable of metastasizing to distant sites where it is typically resistant to available therapy. While striving to prevent or eradicate melanoma, researchers have two significant advantages not shared by those working on many other cancers. The main environmental etiological agent, UV radiation, is known and melanocytic lesions are excisable for molecular analysis from most stages. Yet knowledge about how UV initiates melanoma has been insufficient to achieve prevention, and the understanding of metastatic mechanisms has been inadequate to reduce mortality. Here, we review the value of melanoma mouse models, focusing on these critical early and late stages.
KW - Animals
KW - Disease Models, Animal
KW - Disease Progression
KW - Melanoma/etiology
KW - Mice
KW - Neoplasms, Radiation-Induced/etiology
KW - Skin Neoplasms/etiology
KW - Ultraviolet Rays/adverse effects
UR - http://www.scopus.com/inward/record.url?scp=51749094162&partnerID=8YFLogxK
UR - https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=purepublist2023&SrcAuth=WosAPI&KeyUT=WOS:000259228600006&DestLinkType=FullRecord&DestApp=WOS
U2 - 10.1038/jid.2008.177
DO - 10.1038/jid.2008.177
M3 - Comment/debate
C2 - 18787547
SN - 0022-202X
VL - 128
SP - 2381
EP - 2391
JO - Journal of Investigative Dermatology
JF - Journal of Investigative Dermatology
IS - 10
ER -