From UVs to metastases: Modeling melanoma initiation and progression in the mouse

M. Raza Zaidi, Chi Ping Day, Glenn Merlino

Research output: Contribution to journalComment/debate

59 Scopus citations

Abstract

Cutaneous malignant melanoma is highly invasive and capable of metastasizing to distant sites where it is typically resistant to available therapy. While striving to prevent or eradicate melanoma, researchers have two significant advantages not shared by those working on many other cancers. The main environmental etiological agent, UV radiation, is known and melanocytic lesions are excisable for molecular analysis from most stages. Yet knowledge about how UV initiates melanoma has been insufficient to achieve prevention, and the understanding of metastatic mechanisms has been inadequate to reduce mortality. Here, we review the value of melanoma mouse models, focusing on these critical early and late stages.

Original languageEnglish
Pages (from-to)2381-2391
Number of pages11
JournalJournal of Investigative Dermatology
Volume128
Issue number10
DOIs
StatePublished - Oct 2008

Keywords

  • Animals
  • Disease Models, Animal
  • Disease Progression
  • Melanoma/etiology
  • Mice
  • Neoplasms, Radiation-Induced/etiology
  • Skin Neoplasms/etiology
  • Ultraviolet Rays/adverse effects

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