From pathology to precision medicine in anaplastic large cell lymphoma expressing anaplastic lymphoma kinase (ALK+ ALCL)

Michael T. Werner; Qian Zhang; Mariusz A. Wasik

doi:10.3390/cancers9100138

From pathology to precision medicine in anaplastic large cell lymphoma expressing anaplastic lymphoma kinase (ALK+ ALCL)

Michael T. Werner, Qian Zhang, Mariusz A. Wasik

University of Pennsylvania

Research output: Contribution to journal › Review article › peer-review

8 Scopus citations

Abstract

Anaplastic large cell lymphoma expressing anaplastic lymphoma kinase (ALK+ ALCL) is a distinct subtype of non-Hodgkin lymphoma. In this review, we discuss the historical findings that led to its classification as a unique disease, despite its varied clinical presentation and histology. We discuss the molecular mechanisms underlying ALK+ ALCL pathology and the questions that remain in the field. Finally, we visit how decades of ALK+ ALCL research has yielded more precise drugs that hold promise for the future.

Original language	English
Article number	138
Journal	Cancers
Volume	9
Issue number	10
DOIs	https://doi.org/10.3390/cancers9100138
State	Published - Oct 16 2017
Externally published	Yes

Keywords

ALK+ ALCL
Anaplastic large cell lymphoma
Anaplastic lymphoma kinase
NPM-ALK
Precision medicine

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.3390/cancers9100138

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title = "From pathology to precision medicine in anaplastic large cell lymphoma expressing anaplastic lymphoma kinase (ALK+ ALCL)",

abstract = "Anaplastic large cell lymphoma expressing anaplastic lymphoma kinase (ALK+ ALCL) is a distinct subtype of non-Hodgkin lymphoma. In this review, we discuss the historical findings that led to its classification as a unique disease, despite its varied clinical presentation and histology. We discuss the molecular mechanisms underlying ALK+ ALCL pathology and the questions that remain in the field. Finally, we visit how decades of ALK+ ALCL research has yielded more precise drugs that hold promise for the future.",

keywords = "ALK+ ALCL, Anaplastic large cell lymphoma, Anaplastic lymphoma kinase, NPM-ALK, Precision medicine",

author = "Werner, {Michael T.} and Qian Zhang and Wasik, {Mariusz A.}",

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T1 - From pathology to precision medicine in anaplastic large cell lymphoma expressing anaplastic lymphoma kinase (ALK+ ALCL)

AU - Werner, Michael T.

AU - Zhang, Qian

AU - Wasik, Mariusz A.

PY - 2017/10/16

Y1 - 2017/10/16

N2 - Anaplastic large cell lymphoma expressing anaplastic lymphoma kinase (ALK+ ALCL) is a distinct subtype of non-Hodgkin lymphoma. In this review, we discuss the historical findings that led to its classification as a unique disease, despite its varied clinical presentation and histology. We discuss the molecular mechanisms underlying ALK+ ALCL pathology and the questions that remain in the field. Finally, we visit how decades of ALK+ ALCL research has yielded more precise drugs that hold promise for the future.

AB - Anaplastic large cell lymphoma expressing anaplastic lymphoma kinase (ALK+ ALCL) is a distinct subtype of non-Hodgkin lymphoma. In this review, we discuss the historical findings that led to its classification as a unique disease, despite its varied clinical presentation and histology. We discuss the molecular mechanisms underlying ALK+ ALCL pathology and the questions that remain in the field. Finally, we visit how decades of ALK+ ALCL research has yielded more precise drugs that hold promise for the future.

KW - ALK+ ALCL

KW - Anaplastic large cell lymphoma

KW - Anaplastic lymphoma kinase

KW - NPM-ALK

KW - Precision medicine

UR - http://www.scopus.com/inward/record.url?scp=85031997238&partnerID=8YFLogxK

U2 - 10.3390/cancers9100138

DO - 10.3390/cancers9100138

M3 - Review article

AN - SCOPUS:85031997238

SN - 2072-6694

VL - 9

JO - Cancers

JF - Cancers

IS - 10

M1 - 138

ER -

From pathology to precision medicine in anaplastic large cell lymphoma expressing anaplastic lymphoma kinase (ALK+ ALCL)

Abstract

Keywords

UN SDGs

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