Fighting Resilient Cancers with Iron

Jonathan J. Chen; Lorenzo Galluzzi

doi:10.1016/j.tcb.2017.11.007

Fighting Resilient Cancers with Iron

Jonathan J. Chen, Lorenzo Galluzzi

Research output: Contribution to journal › Short survey › peer-review

55 Scopus citations

Abstract

Tumor progression and resistance to treatment are often accompanied by the polarization of malignant cells towards a mesenchymal or poorly differentiated state. Such a transition generates an accrued vulnerability to the induction of ferroptosis, potentially paving the way to novel therapeutic strategies for targeting residual disease in patients with cancer.

Original language	English
Pages (from-to)	77-78
Number of pages	2
Journal	Trends in Cell Biology
Volume	28
Issue number	2
DOIs	https://doi.org/10.1016/j.tcb.2017.11.007
State	Published - Feb 2018
Externally published	Yes

Keywords

epithelial-to-mesenchymal transition
glutathione
lipid peroxidation
polyunsaturated fatty acids
regulated cell death
statins

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.tcb.2017.11.007

Cite this

@article{632f680ed67c41bab22c53f0abed9cef,

title = "Fighting Resilient Cancers with Iron",

abstract = "Tumor progression and resistance to treatment are often accompanied by the polarization of malignant cells towards a mesenchymal or poorly differentiated state. Such a transition generates an accrued vulnerability to the induction of ferroptosis, potentially paving the way to novel therapeutic strategies for targeting residual disease in patients with cancer.",

keywords = "epithelial-to-mesenchymal transition, glutathione, lipid peroxidation, polyunsaturated fatty acids, regulated cell death, statins",

author = "Chen, {Jonathan J.} and Lorenzo Galluzzi",

note = "Publisher Copyright: {\textcopyright} 2017 Elsevier Ltd",

year = "2018",

month = feb,

doi = "10.1016/j.tcb.2017.11.007",

language = "English",

volume = "28",

pages = "77--78",

journal = "Trends in Cell Biology",

issn = "0962-8924",

publisher = "Elsevier Ltd.",

number = "2",

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TY - JOUR

T1 - Fighting Resilient Cancers with Iron

AU - Chen, Jonathan J.

AU - Galluzzi, Lorenzo

PY - 2018/2

Y1 - 2018/2

N2 - Tumor progression and resistance to treatment are often accompanied by the polarization of malignant cells towards a mesenchymal or poorly differentiated state. Such a transition generates an accrued vulnerability to the induction of ferroptosis, potentially paving the way to novel therapeutic strategies for targeting residual disease in patients with cancer.

AB - Tumor progression and resistance to treatment are often accompanied by the polarization of malignant cells towards a mesenchymal or poorly differentiated state. Such a transition generates an accrued vulnerability to the induction of ferroptosis, potentially paving the way to novel therapeutic strategies for targeting residual disease in patients with cancer.

KW - epithelial-to-mesenchymal transition

KW - glutathione

KW - lipid peroxidation

KW - polyunsaturated fatty acids

KW - regulated cell death

KW - statins

UR - http://www.scopus.com/inward/record.url?scp=85044843452&partnerID=8YFLogxK

U2 - 10.1016/j.tcb.2017.11.007

DO - 10.1016/j.tcb.2017.11.007

M3 - Short survey

C2 - 29223642

AN - SCOPUS:85044843452

SN - 0962-8924

VL - 28

SP - 77

EP - 78

JO - Trends in Cell Biology

JF - Trends in Cell Biology

IS - 2

ER -

Fighting Resilient Cancers with Iron

Abstract

Keywords

UN SDGs

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