Fever-range thermal stress promotes lymphocyte trafficking across high endothelial venules via an interleukin 6 trans-signaling mechanism

Qing Chen, Daniel T. Fisher, Kristen Clancy, Jean-Marc M Gauguet, Wan Chao Wang, Emily Unger, Stefan Rose-John, Ulrich H von Andrian, Heinz Baumann, Sharon S. Evans

Research output: Contribution to journalArticlepeer-review

181 Scopus citations

Abstract

Fever is an evolutionarily conserved response during acute inflammation, although its physiological benefit is poorly understood. Here we show thermal stress in the range of fever temperatures increased the intravascular display of two 'gatekeeper' homing molecules, intercellular adhesion molecule 1 (ICAM-1) and CCL21 chemokine, exclusively in high endothelial venules (HEVs) that are chief portals for the entry of blood-borne lymphocytes into lymphoid organs. Enhanced endothelial expression of ICAM-1 and CCL21 was linked to increased lymphocyte trafficking across HEVs. A bifurcation in the mechanisms controlling HEV adhesion was demonstrated by evidence that the thermal induction of ICAM-1 but not of CCL21 involved an interleukin 6 trans-signaling pathway. Our findings identify the 'HEV axis' as a thermally sensitive alert system that heightens immune surveillance during inflammation by amplifying lymphocyte trafficking to lymphoid organs.

Original languageEnglish
Pages (from-to)1299-1308
Number of pages10
JournalNature Immunology
Volume7
Issue number12
DOIs
StatePublished - Nov 2006

Keywords

  • Animals
  • Cell Adhesion/immunology
  • Chemokine CCL21
  • Chemokines, CC/immunology
  • Chemotaxis, Leukocyte/immunology
  • Electrophoresis, Polyacrylamide Gel
  • Endothelium, Vascular/immunology
  • Female
  • Fever/immunology
  • Flow Cytometry
  • Fluorescent Antibody Technique
  • Immunoblotting
  • Intercellular Adhesion Molecule-1/immunology
  • Interleukin-6/immunology
  • Lymph Nodes/blood supply
  • Lymphocytes/immunology
  • Mice
  • Signal Transduction/immunology
  • Stress, Physiological/immunology
  • Venules/immunology

Fingerprint

Dive into the research topics of 'Fever-range thermal stress promotes lymphocyte trafficking across high endothelial venules via an interleukin 6 trans-signaling mechanism'. Together they form a unique fingerprint.

Cite this