FABP4-tastic Pancreatic Stellate Cells Coddle KITL to Uphold Inherent Microenvironmental Tumor Suppression

Aleksandr Dolskii; Edna Cukierman

doi:10.1158/2159-8290.CD-25-0212

FABP4-tastic Pancreatic Stellate Cells Coddle KITL to Uphold Inherent Microenvironmental Tumor Suppression

Aleksandr Dolskii, Edna Cukierman

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

Oñate and colleagues demonstrate that KITL expression in pancreatic stellate cells is crucial for maintaining the inherent tumor-suppressive function of the pancreatic microenvironment, and its loss enables pancreatic cancer development. This pivotal discovery not only reinforces the century-old hypothesis of natural microenvironmental tumor suppression but also highlights a promising therapeutic avenue whereby restoring KITL expression could reestablish the tumor-suppressive functions of pancreas-resident fibroblastic cells. See related article by Oñate et al., p. 913.

Original language	English
Pages (from-to)	872-874
Number of pages	3
Journal	Cancer Discovery
Volume	15
Issue number	5
DOIs	https://doi.org/10.1158/2159-8290.CD-25-0212
State	Published - May 1 2025

Keywords

Pancreatic Stellate Cells/metabolism
Humans
Tumor Microenvironment
Pancreatic Neoplasms/metabolism
Animals
Fatty Acid-Binding Proteins/metabolism
Proto-Oncogene Proteins/metabolism

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1158/2159-8290.CD-25-0212

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title = "FABP4-tastic Pancreatic Stellate Cells Coddle KITL to Uphold Inherent Microenvironmental Tumor Suppression",

abstract = "O{\~n}ate and colleagues demonstrate that KITL expression in pancreatic stellate cells is crucial for maintaining the inherent tumor-suppressive function of the pancreatic microenvironment, and its loss enables pancreatic cancer development. This pivotal discovery not only reinforces the century-old hypothesis of natural microenvironmental tumor suppression but also highlights a promising therapeutic avenue whereby restoring KITL expression could reestablish the tumor-suppressive functions of pancreas-resident fibroblastic cells. See related article by O{\~n}ate et al., p. 913.",

keywords = "Pancreatic Stellate Cells/metabolism, Humans, Tumor Microenvironment, Pancreatic Neoplasms/metabolism, Animals, Fatty Acid-Binding Proteins/metabolism, Proto-Oncogene Proteins/metabolism",

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doi = "10.1158/2159-8290.CD-25-0212",

language = "English",

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T1 - FABP4-tastic Pancreatic Stellate Cells Coddle KITL to Uphold Inherent Microenvironmental Tumor Suppression

AU - Dolskii, Aleksandr

AU - Cukierman, Edna

PY - 2025/5/1

Y1 - 2025/5/1

N2 - Oñate and colleagues demonstrate that KITL expression in pancreatic stellate cells is crucial for maintaining the inherent tumor-suppressive function of the pancreatic microenvironment, and its loss enables pancreatic cancer development. This pivotal discovery not only reinforces the century-old hypothesis of natural microenvironmental tumor suppression but also highlights a promising therapeutic avenue whereby restoring KITL expression could reestablish the tumor-suppressive functions of pancreas-resident fibroblastic cells. See related article by Oñate et al., p. 913.

AB - Oñate and colleagues demonstrate that KITL expression in pancreatic stellate cells is crucial for maintaining the inherent tumor-suppressive function of the pancreatic microenvironment, and its loss enables pancreatic cancer development. This pivotal discovery not only reinforces the century-old hypothesis of natural microenvironmental tumor suppression but also highlights a promising therapeutic avenue whereby restoring KITL expression could reestablish the tumor-suppressive functions of pancreas-resident fibroblastic cells. See related article by Oñate et al., p. 913.

KW - Pancreatic Stellate Cells/metabolism

KW - Humans

KW - Tumor Microenvironment

KW - Pancreatic Neoplasms/metabolism

KW - Animals

KW - Fatty Acid-Binding Proteins/metabolism

KW - Proto-Oncogene Proteins/metabolism

UR - https://www.scopus.com/pages/publications/105004565352

U2 - 10.1158/2159-8290.CD-25-0212

DO - 10.1158/2159-8290.CD-25-0212

M3 - Article

C2 - 40304501

SN - 2159-8274

VL - 15

SP - 872

EP - 874

JO - Cancer Discovery

JF - Cancer Discovery

IS - 5

ER -

FABP4-tastic Pancreatic Stellate Cells Coddle KITL to Uphold Inherent Microenvironmental Tumor Suppression

Abstract

Keywords

UN SDGs

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