Abstract
Oñate and colleagues demonstrate that KITL expression in pancreatic stellate cells is crucial for maintaining the inherent tumor-suppressive function of the pancreatic microenvironment, and its loss enables pancreatic cancer development. This pivotal discovery not only reinforces the century-old hypothesis of natural microenvironmental tumor suppression but also highlights a promising therapeutic avenue whereby restoring KITL expression could reestablish the tumor-suppressive functions of pancreas-resident fibroblastic cells. See related article by Oñate et al., p. 913.
| Original language | English |
|---|---|
| Pages (from-to) | 872-874 |
| Number of pages | 3 |
| Journal | Cancer Discovery |
| Volume | 15 |
| Issue number | 5 |
| DOIs | |
| State | Published - May 1 2025 |
UN SDGs
This output contributes to the following UN Sustainable Development Goals (SDGs)
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SDG 3 Good Health and Well-being
Keywords
- Animals
- Fatty Acid-Binding Proteins/metabolism
- Humans
- Pancreatic Neoplasms/metabolism
- Pancreatic Stellate Cells/metabolism
- Proto-Oncogene Proteins/metabolism
- Tumor Microenvironment
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