Extended-spectrum beta-lactamase gram-negative sepsis following prostate biopsy: implications for use of fluoroquinolone prophylaxis.

Glenn M. Cannon, Marc C. Smaldone, David L. Paterson

Research output: Contribution to journalArticlepeer-review

18 Scopus citations

Abstract

Extended-spectrum beta-lactamase (ESBL) producing organisms are resistant to penicillins, cephalosporins, aminoglycosides, trimethoprim-sulfamethoxazole, aztreonam, and most fluoroquinolones. We report a case of a 72-year old man who developed septic shock with an ESBL organism after a transrectal ultrasound (TRUS)-guided prostate biopsy despite having received fluoroquinolone prophylaxis. The patient recovered with intravenous ertapenem. Fluoroquinolone resistant bacteria are increasing in prevalence. This needs to be recognized when the antibiotic choice for pre-procedure prophylaxis is made.

Original languageEnglish
Pages (from-to)3653-3655
Number of pages3
JournalCanadian Journal of Urology
Volume14
Issue number4
StatePublished - Aug 2007

Keywords

  • Aged
  • Anti-Bacterial Agents/therapeutic use
  • Antibiotic Prophylaxis
  • Biopsy, Needle/adverse effects
  • Fluoroquinolones/therapeutic use
  • Humans
  • Male
  • Prostate/microbiology
  • Shock, Septic/drug therapy
  • beta-Lactam Resistance

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