Expression of survivin gene in pancreatic carcinoma

Zhi Yong Liang; Tong Hua Liu; Yu Feng Luo; Jian Guan; Shuan Zeng Wei; Jin Ling Cao; Jie Gao; Quan Cai Cui

Expression of survivin gene in pancreatic carcinoma

Zhi Yong Liang, Tong Hua Liu, Yu Feng Luo, Jian Guan, Shuan Zeng Wei, Jin Ling Cao, Jie Gao, Quan Cai Cui

Chinese Academy of Medical Sciences

Research output: Contribution to journal › Article › peer-review

Abstract

OBJECTIVE: To determine the expression status of survivin gene in pancreatic carcinoma. METHODS: Expression of survivin gene was evaluated by immunohistochemistry, Western Blot and RT-PCR in 59 cases of pancreatic carcinoma along with their corresponding adjacent benign tissues, 11 cases of chronic pancreatitis, and 7 pancreatic carcinoma cell lines. RESULTS: The positive expression rate of survivin in pancreatic carcinoma was 72.8% (43/59). There was no relationship between the expression of survivin and tumor stage and differentiation. No expression of survivin was detected in benign tissue adjacent to the tumors as well as in samples of chronic pancreatitis. All 7 pancreatic carcinoma cell lines showed a positive expression of survivin mRNA and protein. CONCLUSIONS: The expression of survivin appears to be tumor specific to some extent in our pancreatic carcinoma samples. Survivin may be an ideal target for therapy against pancreatic carcinoma.

Original language	English
Pages (from-to)	67-70
Number of pages	4
Journal	Chinese Journal of Pathology
Volume	34
Issue number	2
State	Published - Feb 2005
Externally published	Yes

Cite this

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title = "Expression of survivin gene in pancreatic carcinoma",

abstract = "OBJECTIVE: To determine the expression status of survivin gene in pancreatic carcinoma. METHODS: Expression of survivin gene was evaluated by immunohistochemistry, Western Blot and RT-PCR in 59 cases of pancreatic carcinoma along with their corresponding adjacent benign tissues, 11 cases of chronic pancreatitis, and 7 pancreatic carcinoma cell lines. RESULTS: The positive expression rate of survivin in pancreatic carcinoma was 72.8% (43/59). There was no relationship between the expression of survivin and tumor stage and differentiation. No expression of survivin was detected in benign tissue adjacent to the tumors as well as in samples of chronic pancreatitis. All 7 pancreatic carcinoma cell lines showed a positive expression of survivin mRNA and protein. CONCLUSIONS: The expression of survivin appears to be tumor specific to some extent in our pancreatic carcinoma samples. Survivin may be an ideal target for therapy against pancreatic carcinoma.",

author = "Liang, {Zhi Yong} and Liu, {Tong Hua} and Luo, {Yu Feng} and Jian Guan and Wei, {Shuan Zeng} and Cao, {Jin Ling} and Jie Gao and Cui, {Quan Cai}",

year = "2005",

month = feb,

language = "English",

volume = "34",

pages = "67--70",

journal = "Chinese Journal of Pathology",

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TY - JOUR

T1 - Expression of survivin gene in pancreatic carcinoma

AU - Liang, Zhi Yong

AU - Liu, Tong Hua

AU - Luo, Yu Feng

AU - Guan, Jian

AU - Wei, Shuan Zeng

AU - Cao, Jin Ling

AU - Gao, Jie

AU - Cui, Quan Cai

PY - 2005/2

Y1 - 2005/2

N2 - OBJECTIVE: To determine the expression status of survivin gene in pancreatic carcinoma. METHODS: Expression of survivin gene was evaluated by immunohistochemistry, Western Blot and RT-PCR in 59 cases of pancreatic carcinoma along with their corresponding adjacent benign tissues, 11 cases of chronic pancreatitis, and 7 pancreatic carcinoma cell lines. RESULTS: The positive expression rate of survivin in pancreatic carcinoma was 72.8% (43/59). There was no relationship between the expression of survivin and tumor stage and differentiation. No expression of survivin was detected in benign tissue adjacent to the tumors as well as in samples of chronic pancreatitis. All 7 pancreatic carcinoma cell lines showed a positive expression of survivin mRNA and protein. CONCLUSIONS: The expression of survivin appears to be tumor specific to some extent in our pancreatic carcinoma samples. Survivin may be an ideal target for therapy against pancreatic carcinoma.

AB - OBJECTIVE: To determine the expression status of survivin gene in pancreatic carcinoma. METHODS: Expression of survivin gene was evaluated by immunohistochemistry, Western Blot and RT-PCR in 59 cases of pancreatic carcinoma along with their corresponding adjacent benign tissues, 11 cases of chronic pancreatitis, and 7 pancreatic carcinoma cell lines. RESULTS: The positive expression rate of survivin in pancreatic carcinoma was 72.8% (43/59). There was no relationship between the expression of survivin and tumor stage and differentiation. No expression of survivin was detected in benign tissue adjacent to the tumors as well as in samples of chronic pancreatitis. All 7 pancreatic carcinoma cell lines showed a positive expression of survivin mRNA and protein. CONCLUSIONS: The expression of survivin appears to be tumor specific to some extent in our pancreatic carcinoma samples. Survivin may be an ideal target for therapy against pancreatic carcinoma.

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M3 - Article

SN - 0529-5807

VL - 34

SP - 67

EP - 70

JO - Chinese Journal of Pathology

JF - Chinese Journal of Pathology

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ER -

Expression of survivin gene in pancreatic carcinoma

Abstract

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