Examining the impact of gene variants on histone lysine methylation

doi:10.1016/j.bbagrm.2014.05.014

Examining the impact of gene variants on histone lysine methylation

Harvard University

Research output: Contribution to journal › Review article › peer-review

30 Scopus citations

Abstract

In recent years, there has been a boom in the amount of genome-wide sequencing data that has uncovered important and unappreciated links between certain genes, families of genes and enzymatic processes and diseases such as cancer. Such studies have highlighted the impact that chromatin modifying enzymes could have in cancer and other genetic diseases. In this review, we summarize characterized mutations and single nucleotide polymorphisms (SNPs) in histone lysine methyltransferases (KMTs), histone lysine demethylases (KDMs) and histones. We primarily focus on variants with strong disease correlations and discuss how they could impact histone lysine methylation dynamics and gene regulation. This article is part of a Special Issue entitled: Methylation: A Multifaceted Modification - looking at transcription and beyond.

Original language	English
Pages (from-to)	1463-1476
Number of pages	14
Journal	Biochimica et Biophysica Acta - Gene Regulatory Mechanisms
Volume	1839
Issue number	12
DOIs	https://doi.org/10.1016/j.bbagrm.2014.05.014
State	Published - Dec 1 2014
Externally published	Yes

Keywords

EZH2
Histone
KDM
KMT
SNP
Somatic mutation

Access to Document

10.1016/j.bbagrm.2014.05.014

Cite this

@article{0b007c8ad9594cfc9b9ab5c156dd5180,

title = "Examining the impact of gene variants on histone lysine methylation",

abstract = "In recent years, there has been a boom in the amount of genome-wide sequencing data that has uncovered important and unappreciated links between certain genes, families of genes and enzymatic processes and diseases such as cancer. Such studies have highlighted the impact that chromatin modifying enzymes could have in cancer and other genetic diseases. In this review, we summarize characterized mutations and single nucleotide polymorphisms (SNPs) in histone lysine methyltransferases (KMTs), histone lysine demethylases (KDMs) and histones. We primarily focus on variants with strong disease correlations and discuss how they could impact histone lysine methylation dynamics and gene regulation. This article is part of a Special Issue entitled: Methylation: A Multifaceted Modification - looking at transcription and beyond.",

keywords = "EZH2, Histone, KDM, KMT, SNP, Somatic mutation",

note = "Publisher Copyright: {\textcopyright} 2014 Elsevier B.V.",

year = "2014",

month = dec,

day = "1",

doi = "10.1016/j.bbagrm.2014.05.014",

language = "English",

volume = "1839",

pages = "1463--1476",

journal = "Biochimica et Biophysica Acta - Gene Regulatory Mechanisms",

issn = "1874-9399",

publisher = "Elsevier",

number = "12",

}

TY - JOUR

T1 - Examining the impact of gene variants on histone lysine methylation

PY - 2014/12/1

Y1 - 2014/12/1

N2 - In recent years, there has been a boom in the amount of genome-wide sequencing data that has uncovered important and unappreciated links between certain genes, families of genes and enzymatic processes and diseases such as cancer. Such studies have highlighted the impact that chromatin modifying enzymes could have in cancer and other genetic diseases. In this review, we summarize characterized mutations and single nucleotide polymorphisms (SNPs) in histone lysine methyltransferases (KMTs), histone lysine demethylases (KDMs) and histones. We primarily focus on variants with strong disease correlations and discuss how they could impact histone lysine methylation dynamics and gene regulation. This article is part of a Special Issue entitled: Methylation: A Multifaceted Modification - looking at transcription and beyond.

AB - In recent years, there has been a boom in the amount of genome-wide sequencing data that has uncovered important and unappreciated links between certain genes, families of genes and enzymatic processes and diseases such as cancer. Such studies have highlighted the impact that chromatin modifying enzymes could have in cancer and other genetic diseases. In this review, we summarize characterized mutations and single nucleotide polymorphisms (SNPs) in histone lysine methyltransferases (KMTs), histone lysine demethylases (KDMs) and histones. We primarily focus on variants with strong disease correlations and discuss how they could impact histone lysine methylation dynamics and gene regulation. This article is part of a Special Issue entitled: Methylation: A Multifaceted Modification - looking at transcription and beyond.

KW - EZH2

KW - Histone

KW - KDM

KW - KMT

KW - SNP

KW - Somatic mutation

UR - http://www.scopus.com/inward/record.url?scp=84913597263&partnerID=8YFLogxK

U2 - 10.1016/j.bbagrm.2014.05.014

DO - 10.1016/j.bbagrm.2014.05.014

M3 - Review article

C2 - 24859469

SN - 1874-9399

VL - 1839

SP - 1463

EP - 1476

JO - Biochimica et Biophysica Acta - Gene Regulatory Mechanisms

JF - Biochimica et Biophysica Acta - Gene Regulatory Mechanisms

IS - 12

ER -

Examining the impact of gene variants on histone lysine methylation

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this