Examining associations between prenatal biomarkers of oxidative stress and ASD-related outcomes using quantile regression

Meghan E Carey; Juliette Rando; Stepan Melnyk; S Jill James; Nathaniel Snyder; Carolyn Salafia; Lisa A Croen; M Daniele Fallin; Irva Hertz-Picciotto; Heather Volk; Craig Newschaffer; Kristen Lyall

doi:10.1007/s10803-022-05625-9

Examining associations between prenatal biomarkers of oxidative stress and ASD-related outcomes using quantile regression

Meghan E Carey, Juliette Rando, Stepan Melnyk, S Jill James, Nathaniel Snyder, Carolyn Salafia, Lisa A Croen, M Daniele Fallin, Irva Hertz-Picciotto, Heather Volk, Craig Newschaffer, Kristen Lyall

Cancer Signaling and Microenvironment (CSM)

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

We examined associations between prenatal oxidative stress (OS) and child autism-related outcomes. Women with an autistic child were followed through a subsequent pregnancy and that younger sibling's childhood. Associations between glutathione (GSH), glutathione disulfide (GSSG), 8-oxo-deoxyguanine (8-OHdG), and nitrotyrosine and younger sibling Social Responsiveness Scale (SRS) scores were examined using quantile regression. Increasing GSH:GSSG (suggesting decreasing OS) was associated with minor increases in SRS scores (50th percentile β: 1.78, 95% CI: 0.67, 3.06); no other associations were observed. Results from this cohort with increased risk for autism do not support a strong relationship between OS in late pregnancy and autism-related outcomes. Results may be specific to those with enriched autism risk; future work should consider other timepoints and biomarkers.

Original language	English
Pages (from-to)	2975-2985
Number of pages	11
Journal	Journal of Autism and Developmental Disorders
Volume	53
Issue number	8
DOIs	https://doi.org/10.1007/s10803-022-05625-9
State	Published - Aug 2023

Keywords

Child
Humans
Female
Pregnancy
Autism Spectrum Disorder/diagnosis
Glutathione Disulfide
Vitamins
Oxidative Stress
Biomarkers
Glutathione/metabolism
Oxidative stress
Epidemiology
Autism spectrum disorder
Risk factors
Cohort
Neurodevelopment

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10.1007/s10803-022-05625-9

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Carey, M. E., Rando, J., Melnyk, S., James, S. J., Snyder, N., Salafia, C., Croen, L. A., Fallin, M. D., Hertz-Picciotto, I., Volk, H., Newschaffer, C., & Lyall, K. (2023). Examining associations between prenatal biomarkers of oxidative stress and ASD-related outcomes using quantile regression. Journal of Autism and Developmental Disorders, 53(8), 2975-2985. https://doi.org/10.1007/s10803-022-05625-9

@article{faa0aebe38904d67b7e0f52f74ab04fc,

title = "Examining associations between prenatal biomarkers of oxidative stress and ASD-related outcomes using quantile regression",

abstract = "We examined associations between prenatal oxidative stress (OS) and child autism-related outcomes. Women with an autistic child were followed through a subsequent pregnancy and that younger sibling's childhood. Associations between glutathione (GSH), glutathione disulfide (GSSG), 8-oxo-deoxyguanine (8-OHdG), and nitrotyrosine and younger sibling Social Responsiveness Scale (SRS) scores were examined using quantile regression. Increasing GSH:GSSG (suggesting decreasing OS) was associated with minor increases in SRS scores (50th percentile β: 1.78, 95% CI: 0.67, 3.06); no other associations were observed. Results from this cohort with increased risk for autism do not support a strong relationship between OS in late pregnancy and autism-related outcomes. Results may be specific to those with enriched autism risk; future work should consider other timepoints and biomarkers.",

keywords = "Child, Humans, Female, Pregnancy, Autism Spectrum Disorder/diagnosis, Glutathione Disulfide, Vitamins, Oxidative Stress, Biomarkers, Glutathione/metabolism, Oxidative stress, Epidemiology, Autism spectrum disorder, Risk factors, Cohort, Neurodevelopment",

author = "Carey, {Meghan E} and Juliette Rando and Stepan Melnyk and James, {S Jill} and Nathaniel Snyder and Carolyn Salafia and Croen, {Lisa A} and Fallin, {M Daniele} and Irva Hertz-Picciotto and Heather Volk and Craig Newschaffer and Kristen Lyall",

note = "{\textcopyright} 2022. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.",

year = "2023",

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Carey, ME, Rando, J, Melnyk, S, James, SJ, Snyder, N, Salafia, C, Croen, LA, Fallin, MD, Hertz-Picciotto, I, Volk, H, Newschaffer, C & Lyall, K 2023, 'Examining associations between prenatal biomarkers of oxidative stress and ASD-related outcomes using quantile regression', Journal of Autism and Developmental Disorders, vol. 53, no. 8, pp. 2975-2985. https://doi.org/10.1007/s10803-022-05625-9

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AU - Rando, Juliette

AU - Melnyk, Stepan

AU - James, S Jill

AU - Snyder, Nathaniel

AU - Salafia, Carolyn

AU - Croen, Lisa A

AU - Fallin, M Daniele

AU - Hertz-Picciotto, Irva

AU - Volk, Heather

AU - Newschaffer, Craig

AU - Lyall, Kristen

PY - 2023/8

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N2 - We examined associations between prenatal oxidative stress (OS) and child autism-related outcomes. Women with an autistic child were followed through a subsequent pregnancy and that younger sibling's childhood. Associations between glutathione (GSH), glutathione disulfide (GSSG), 8-oxo-deoxyguanine (8-OHdG), and nitrotyrosine and younger sibling Social Responsiveness Scale (SRS) scores were examined using quantile regression. Increasing GSH:GSSG (suggesting decreasing OS) was associated with minor increases in SRS scores (50th percentile β: 1.78, 95% CI: 0.67, 3.06); no other associations were observed. Results from this cohort with increased risk for autism do not support a strong relationship between OS in late pregnancy and autism-related outcomes. Results may be specific to those with enriched autism risk; future work should consider other timepoints and biomarkers.

AB - We examined associations between prenatal oxidative stress (OS) and child autism-related outcomes. Women with an autistic child were followed through a subsequent pregnancy and that younger sibling's childhood. Associations between glutathione (GSH), glutathione disulfide (GSSG), 8-oxo-deoxyguanine (8-OHdG), and nitrotyrosine and younger sibling Social Responsiveness Scale (SRS) scores were examined using quantile regression. Increasing GSH:GSSG (suggesting decreasing OS) was associated with minor increases in SRS scores (50th percentile β: 1.78, 95% CI: 0.67, 3.06); no other associations were observed. Results from this cohort with increased risk for autism do not support a strong relationship between OS in late pregnancy and autism-related outcomes. Results may be specific to those with enriched autism risk; future work should consider other timepoints and biomarkers.

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KW - Humans

KW - Female

KW - Pregnancy

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KW - Biomarkers

KW - Glutathione/metabolism

KW - Oxidative stress

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KW - Autism spectrum disorder

KW - Risk factors

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JO - Journal of Autism and Developmental Disorders

JF - Journal of Autism and Developmental Disorders

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ER -

Examining associations between prenatal biomarkers of oxidative stress and ASD-related outcomes using quantile regression

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