Ethylene bis-imidazoles are highly potent and selective activators for isozymes VA and VII of carbonic anhydrase, with a potential nootropic effect

Bogdan Draghici, Daniela Vullo, Suleyman Akocak, Ellen A. Walker, Claudiu T. Supuran, Marc A. Ilies

Research output: Contribution to journalArticlepeer-review

57 Scopus citations

Abstract

A series of ethylene bis-imidazoles was synthesized via a novel microwave-mediated synthesis. Biological testing on eight isozymes of carbonic anhydrase (CA) present in the human brain revealed compounds with nanomolar potency against CA VA and CA VII, also displaying excellent selectivity against other CA isozymes present in this organ.

Original languageEnglish
Pages (from-to)5980-5983
Number of pages4
JournalChemical Communications
Volume50
Issue number45
DOIs
StatePublished - May 8 2014
Externally publishedYes

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