Epigenetic modulators provide a path to understanding disease and therapeutic opportunity

Madison A Honer; Benjamin I Ferman; Zach H Gray; Elena A Bondarenko; Johnathan R Whetstine

doi:10.1101/gad.351444.123

Epigenetic modulators provide a path to understanding disease and therapeutic opportunity

Madison A Honer, Benjamin I Ferman, Zach H Gray, Elena A Bondarenko, Johnathan R Whetstine

Research output: Contribution to journal › Review article › peer-review

1 Scopus citations

Abstract

The discovery of epigenetic modulators (writers, erasers, readers, and remodelers) has shed light on previously underappreciated biological mechanisms that promote diseases. With these insights, novel biomarkers and innovative combination therapies can be used to address challenging and difficult to treat disease states. This review highlights key mechanisms that epigenetic writers, erasers, readers, and remodelers control, as well as their connection with disease states and recent advances in associated epigenetic therapies.

Original language	English
Pages (from-to)	473-503
Number of pages	31
Journal	Genes & Development
Volume	38
Issue number	11-12
Early online date	May 24 2024
DOIs	https://doi.org/10.1101/gad.351444.123 https://doi.org/10.1101/gad.351444.123
State	Published - Jun 19 2024

Keywords

acetylation
bromodomain
chromatin remodeling
demethylase
DNA and histone modifications
DNA methylation
ecDNA
epigenetics
SWI/SNF
transcription]

Access to Document

Cite this

@article{e220619ddf684b228c8da45a48846346,

title = "Epigenetic modulators provide a path to understanding disease and therapeutic opportunity",

abstract = "The discovery of epigenetic modulators (writers, erasers, readers, and remodelers) has shed light on previously underappreciated biological mechanisms that promote diseases. With these insights, novel biomarkers and innovative combination therapies can be used to address challenging and difficult to treat disease states. This review highlights key mechanisms that epigenetic writers, erasers, readers, and remodelers control, as well as their connection with disease states and recent advances in associated epigenetic therapies.",

keywords = "acetylation, bromodomain, chromatin remodeling, demethylase, DNA and histone modifications, DNA methylation, ecDNA, epigenetics, SWI/SNF, transcription]",

author = "Honer, {Madison A} and Ferman, {Benjamin I} and Gray, {Zach H} and Bondarenko, {Elena A} and Whetstine, {Johnathan R}",

note = "Publisher Copyright: {\textcopyright} 2024 Honer et al.",

year = "2024",

month = jun,

day = "19",

doi = "10.1101/gad.351444.123",

language = "English",

volume = "38",

pages = "473--503",

journal = "Genes & Development",

issn = "0890-9369",

publisher = "Cold Spring Harbor Laboratory Press",

number = "11-12",

}

TY - JOUR

T1 - Epigenetic modulators provide a path to understanding disease and therapeutic opportunity

AU - Honer, Madison A

AU - Ferman, Benjamin I

AU - Gray, Zach H

AU - Bondarenko, Elena A

AU - Whetstine, Johnathan R

PY - 2024/6/19

Y1 - 2024/6/19

N2 - The discovery of epigenetic modulators (writers, erasers, readers, and remodelers) has shed light on previously underappreciated biological mechanisms that promote diseases. With these insights, novel biomarkers and innovative combination therapies can be used to address challenging and difficult to treat disease states. This review highlights key mechanisms that epigenetic writers, erasers, readers, and remodelers control, as well as their connection with disease states and recent advances in associated epigenetic therapies.

AB - The discovery of epigenetic modulators (writers, erasers, readers, and remodelers) has shed light on previously underappreciated biological mechanisms that promote diseases. With these insights, novel biomarkers and innovative combination therapies can be used to address challenging and difficult to treat disease states. This review highlights key mechanisms that epigenetic writers, erasers, readers, and remodelers control, as well as their connection with disease states and recent advances in associated epigenetic therapies.

KW - acetylation

KW - bromodomain

KW - chromatin remodeling

KW - demethylase

KW - DNA and histone modifications

KW - DNA methylation

KW - ecDNA

KW - epigenetics

KW - SWI/SNF

KW - transcription]

UR - http://www.scopus.com/inward/record.url?scp=85199127881&partnerID=8YFLogxK

U2 - 10.1101/gad.351444.123

DO - 10.1101/gad.351444.123

M3 - Review article

C2 - 38914477

SN - 0890-9369

VL - 38

SP - 473

EP - 503

JO - Genes & Development

JF - Genes & Development

IS - 11-12

ER -

Epigenetic modulators provide a path to understanding disease and therapeutic opportunity

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Study Results from Fox Chase Cancer Center Provide New Insights into Drug Research (Epigenetic Modulators Provide a Path To Understanding Disease and Therapeutic Opportunity)

Cite this

Epigenetic modulators provide a path to understanding disease and therapeutic opportunity

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Press/Media

Study Results from Fox Chase Cancer Center Provide New Insights into Drug Research (Epigenetic Modulators Provide a Path To Understanding Disease and Therapeutic Opportunity)

Cite this