Epigenetic escape of immunosurveillance by malignant cell precursors

Claudia Galassi, Lorenzo Galluzzi

Research output: Contribution to journalComment/debate

4 Scopus citations

Abstract

Newly formed malignant cells must escape immunosurveillance to generate progressing neoplastic lesions of clinical relevance. Recent data indicate that the immunogenicity of nascent cancer cells, at least in some settings, is dictated by inherent epigenetic mechanisms rather than by immunoediting and the consequent Darwinian selection of poorly immunogenic phenotypes.

Original languageEnglish
Article numbere114050
Pages (from-to)e114050
JournalEMBO Journal
Volume42
Issue number10
DOIs
StatePublished - Apr 15 2023
Externally publishedYes

Keywords

  • cancer stem cells
  • CSDE1
  • immunotherapy
  • intratumoral heterogeneity
  • SMYD3
  • STAT1
  • Tumor Escape/genetics
  • Epigenomics
  • Humans
  • Monitoring, Immunologic
  • Neoplasms/genetics
  • Immunotherapy
  • Immunologic Surveillance/genetics

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