Epidermal growth factor receptor (EGFR) mutations in small cell lung cancers: Two cases and a review of the literature

Bradford J. Siegele, Konstantin Shilo, Bo H. Chao, David P. Carbone, Weiqiang Zhao, Olga Ioffe, Wilbur A. Franklin, Martin J. Edelman, Dara L. Aisner

Research output: Contribution to journalArticlepeer-review

18 Scopus citations

Abstract

Activating mutations in the epidermal growth factor receptor (EGFR) gene are exceedingly rare in small cell lung cancer (SCLC). We present two cases of SCLC harboring EGFR mutations, one in an 82 year-old male smoker with a combined SCLC and adenocarcinoma with a novel D855H point mutation in exon 21, and the second in a 68 year-old female never smoker with the L858R point mutation in exon 21. The cases, accompanied by a review of the literature, highlight the importance of integration of clinicopathologic considerations and adherence to recently promulgated Guideline recommendations for molecular testing in lung cancer.

Original languageEnglish
Pages (from-to)65-72
Number of pages8
JournalLung Cancer
Volume95
DOIs
StatePublished - May 1 2016
Externally publishedYes

Keywords

  • Adenocarcinoma
  • EGFR
  • Guideline
  • Molecular
  • Pathology
  • SCLC

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