Abstract
A recurrent theme in molecular biology is that of "action at a distance" along DNA. We consider various mechanisms of action of transcriptional enhancers as a well-characterised example of interaction between widely separated DNA-bound proteins. The role of promoter- and enhancer-binding proteins in the formation of a stable promoter complex, and the mechanisms of interaction between multiple activatory DNA sequences is also discussed.
| Translated title of the contribution | Enhancers, DNA loops and stable complexes: a mechanism of transcription activation |
|---|---|
| Original language | Russian |
| Pages (from-to) | 909-919 |
| Number of pages | 11 |
| Journal | Molekulyarnaya Biologiya |
| Volume | 24 |
| Issue number | 4 |
| State | Published - 1990 |
Keywords
- Allosteric Regulation
- Animals
- Enhancer Elements, Genetic/genetics
- Eukaryotic Cells
- Models, Genetic
- Nucleic Acid Conformation
- Trans-Activators/genetics
- Transcription, Genetic