TY - JOUR
T1 - Engineered mesenchymal stem cells for targeting solid tumors
T2 - Therapeutic potential beyond regenerative therapy
AU - Cheng, Shen
AU - Nethi, Susheel Kumar
AU - Rathi, Sneha
AU - Layek, Buddhadev
AU - Prabha, Swayam
N1 - Copyright © 2019 by The American Society for Pharmacology and Experimental Therapeutics.
PY - 2019
Y1 - 2019
N2 - Mesenchymal stem cells (MSCs) have previously demonstrated considerable promise in regenerative medicine based on their ability to proliferate and differentiate into cells of different lineages. More recently, there has been a significant interest in using MSCs as cellular vehicles for targeted cancer therapy by exploiting their tumor homing properties. Initial studies focused on using genetically modified MSCs for targeted delivery of various proapoptotic, antiangiogenic, and therapeutic proteins to a wide variety of tumors. However, their use as drug delivery vehicles has been limited by poor drug load capacity. This review discusses various strategies for the nongenetic modification of MSCs that allows their use in tumor-targeted delivery of small molecule chemotherapeutic agents.
AB - Mesenchymal stem cells (MSCs) have previously demonstrated considerable promise in regenerative medicine based on their ability to proliferate and differentiate into cells of different lineages. More recently, there has been a significant interest in using MSCs as cellular vehicles for targeted cancer therapy by exploiting their tumor homing properties. Initial studies focused on using genetically modified MSCs for targeted delivery of various proapoptotic, antiangiogenic, and therapeutic proteins to a wide variety of tumors. However, their use as drug delivery vehicles has been limited by poor drug load capacity. This review discusses various strategies for the nongenetic modification of MSCs that allows their use in tumor-targeted delivery of small molecule chemotherapeutic agents.
KW - Animals
KW - Cell Engineering
KW - Cell- and Tissue-Based Therapy/methods
KW - Humans
KW - Mesenchymal Stem Cells/cytology
KW - Neoplasms/pathology
KW - Translational Research, Biomedical
UR - http://www.scopus.com/inward/record.url?scp=85070055463&partnerID=8YFLogxK
U2 - 10.1124/jpet.119.259796
DO - 10.1124/jpet.119.259796
M3 - Article
C2 - 31175219
AN - SCOPUS:85070055463
SN - 0022-3565
VL - 370
SP - 231
EP - 241
JO - Journal of Pharmacology and Experimental Therapeutics
JF - Journal of Pharmacology and Experimental Therapeutics
IS - 2
ER -
