Endosonographic diagnosis of recurrent gastrointestinal stromal tumors associated with Carney's syndrome

Michael T. Lipcan, David E. Loren, Juan P. Palazzo, Marluce Bibbo, Anthony J. Dimarino, Sidney Cohen

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

This is a report of a patient who manifests all of the features of Carney's syndrome, including gastrointestinal stromal tumors (GISTs), extra-adrenal paragangliomas, and pulmonary chondromas. The patient underwent surgical resection of a gastric GIST; a retroperitoneal, nonfunctional paraganglioma; and a mediastinal, catecholamine-secreting paraganglioma (pheochromocytoma). Recently, new gastric GISTs were diagnosed by endoscopic, ultrasound-guided, fine-needle aspiration (EUS-FNA) biopsy and were resected. Recurrence of stromal tumors following complete resection is common in Carney's syndrome and presents considerable management challenges. This case illustrates several important points: (1) Carney's syndrome, although rare, should be considered in patients with foregut GISTs; (2) GISTs associated with Carney's syndrome, like sporadic gastric GISTs, may have a more indolent clinical course; and (3) EUS-FNA may be useful for the diagnosis and management of GISTs in this syndrome.

Original languageEnglish
Pages (from-to)169-174
Number of pages6
JournalGastroenterology
Volume128
Issue number1
DOIs
StatePublished - Jan 2005

Keywords

  • Chondroma/diagnosis
  • Endosonography
  • Female
  • Gastrointestinal Stromal Tumors/diagnosis
  • Humans
  • Lung Neoplasms/diagnosis
  • Mediastinal Neoplasms/diagnosis
  • Middle Aged
  • Neoplasm Recurrence, Local/diagnosis
  • Neoplasms, Multiple Primary/diagnosis
  • Paraganglioma, Extra-Adrenal/diagnosis
  • Retroperitoneal Neoplasms/diagnosis
  • Stomach Neoplasms/diagnosis

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