Abstract
The endocannabinoid system is recognized as an important contributor to both homeostasis and pathological responses in the central nervous system (CNS). It is comprised of endogenously produced cannabinoid ligands, their receptors, and the enzymes responsible for their degradation. Included among the important homeostatic functions are regulation of synaptic transmission, metabolism and appetite, and pain processing. Alterations in endocannabinoid function can play both positive and negative roles under pathological conditions, influencing metabolism and appetite, pain, and inflammation. Modulation of endocannabinoid function has become an important therapeutic target for these areas, with both naturally occurring and synthetic ligands being investigated in the clinic as well as in animal models. In addition, endocannabinoid modulation may also be an important therapeutic strategy for other CNS disorders, including mood disorders and substance abuse.
Original language | English |
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Title of host publication | Encyclopedia of the Neurological Sciences |
Publisher | Elsevier Inc. |
Pages | 42-47 |
Number of pages | 6 |
ISBN (Electronic) | 9780123851574 |
ISBN (Print) | 9780123851581 |
DOIs | |
State | Published - Jan 1 2014 |
Externally published | Yes |
Keywords
- 2-Arachidonyl glycerol
- Arachidonylethanolamide (anandamine)
- Cannabinoid 1 receptor
- Cannabinoid 2 receptor
- Endocannabinoid
- Excitotoxic injury
- Fatty acid amide hydrolase
- Inflammation
- Metabolism
- Monoacylglycerol lipase
- Mood disorders
- Neuroprotection
- Pain
- Stroke