TY - JOUR
T1 - Emerging role of bacteria in oral carcinogenesis
T2 - A review with special reference to perio-pathogenic bacteria
AU - Perera, Manosha
AU - Al-Hebshi, Nezar Noor
AU - Speicher, David J.
AU - Perera, Irosha
AU - Johnson, Newell W.
N1 - Publisher Copyright:
© 2016 Manosha Perera et al.
PY - 2016
Y1 - 2016
N2 - Oral cancer, primarily oral squamous cell carcinoma (OSCC), continues to be a major global health problem with high incidence and low survival rates. While the major risk factors for this malignancy, mostly lifestyle related, have been identified, around 15% of oral cancer cases remain unexplained. In light of evidence implicating bacteria in the aetiology of some cancer types, several epidemiological studies have been conducted in the last decade, employing methodologies ranging from traditional culture techniques to 16S rRNA metagenomics, to assess the possible role of bacteria in OSCC. While these studies have demonstrated differences in microbial composition between cancerous and healthy tissues, they have failed to agree on specific bacteria or patterns of oral microbial dysbiosis to implicate in OSCC. On the contrary, some oral taxa, particularly Porphyromonas gingivalis and Fusobacterium nucleatum, show strong oral carcinogenic potential in vitro and in animal studies. Bacteria are thought to contribute to oral carcinogenesis via inhibition of apoptosis, activation of cell proliferation, promotion of cellular invasion, induction of chronic inflammation, and production of carcinogens. This narrative review provides a critical analysis of and an update on the association between bacteria and oral carcinogenesis and the possible mechanisms underlying it.
AB - Oral cancer, primarily oral squamous cell carcinoma (OSCC), continues to be a major global health problem with high incidence and low survival rates. While the major risk factors for this malignancy, mostly lifestyle related, have been identified, around 15% of oral cancer cases remain unexplained. In light of evidence implicating bacteria in the aetiology of some cancer types, several epidemiological studies have been conducted in the last decade, employing methodologies ranging from traditional culture techniques to 16S rRNA metagenomics, to assess the possible role of bacteria in OSCC. While these studies have demonstrated differences in microbial composition between cancerous and healthy tissues, they have failed to agree on specific bacteria or patterns of oral microbial dysbiosis to implicate in OSCC. On the contrary, some oral taxa, particularly Porphyromonas gingivalis and Fusobacterium nucleatum, show strong oral carcinogenic potential in vitro and in animal studies. Bacteria are thought to contribute to oral carcinogenesis via inhibition of apoptosis, activation of cell proliferation, promotion of cellular invasion, induction of chronic inflammation, and production of carcinogens. This narrative review provides a critical analysis of and an update on the association between bacteria and oral carcinogenesis and the possible mechanisms underlying it.
KW - Bacteria
KW - Carcinoma
KW - Dysbiosis
KW - Inflammation
KW - Microbiome
KW - Mouth
KW - Squamous cell
UR - http://www.scopus.com/inward/record.url?scp=85011067260&partnerID=8YFLogxK
U2 - 10.3402/jom.v8.32762
DO - 10.3402/jom.v8.32762
M3 - Review article
C2 - 27677454
AN - SCOPUS:85011067260
SN - 2000-2297
VL - 8
SP - 32762
JO - Journal of Oral Microbiology
JF - Journal of Oral Microbiology
IS - 1
M1 - 32762
ER -