Effect of Acetylation of Histone H4 on Communication in Chromatin

E. V. Nizovtseva; N. S. Gerasimova; V. M. Studitsky

doi:10.3103/S0096392519040114

Effect of Acetylation of Histone H4 on Communication in Chromatin

E. V. Nizovtseva, N. S. Gerasimova, V. M. Studitsky

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Abstract

Abstract: Long-distance interaction plays an important role in the regulation of eukaryotic genes. Chromatin structure is involved in the process, but the role of histone modifications has not been studied. In the present work, the role of acetylation Н4K16 (Н4K16-Ac) to enhancer-promoter communication (EPC) was analyzed. This modification is associated with euchromatin and is involved in the decompaction of chromatin fibers. We have shown that the effect of H4K16-Ac on EPC in vitro depends on the level of chromatin assembly. EPC in chromatin, which lacks nucleosomes at random positions on DNA, is inhibited in the presence of H4K16-Aс. At the same time, EPC in chromatin, in which nucleosomes occupy all available positions on DNA, is somewhat stimulated in the presence of H4K16-Aс.

Original language	English
Pages (from-to)	246-249
Number of pages	4
Journal	Moscow University Biological Sciences Bulletin
Volume	74
Issue number	4
DOIs	https://doi.org/10.3103/S0096392519040114
State	Published - Oct 1 2019

Keywords

acetylation
chromatin
enhancers
histones
modifications
regulation
transcription

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title = "Effect of Acetylation of Histone H4 on Communication in Chromatin",

abstract = "Abstract: Long-distance interaction plays an important role in the regulation of eukaryotic genes. Chromatin structure is involved in the process, but the role of histone modifications has not been studied. In the present work, the role of acetylation Н4K16 (Н4K16-Ac) to enhancer-promoter communication (EPC) was analyzed. This modification is associated with euchromatin and is involved in the decompaction of chromatin fibers. We have shown that the effect of H4K16-Ac on EPC in vitro depends on the level of chromatin assembly. EPC in chromatin, which lacks nucleosomes at random positions on DNA, is inhibited in the presence of H4K16-Aс. At the same time, EPC in chromatin, in which nucleosomes occupy all available positions on DNA, is somewhat stimulated in the presence of H4K16-Aс.",

keywords = "acetylation, chromatin, enhancers, histones, modifications, regulation, transcription",

author = "Nizovtseva, {E. V.} and Gerasimova, {N. S.} and Studitsky, {V. M.}",

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TY - JOUR

T1 - Effect of Acetylation of Histone H4 on Communication in Chromatin

AU - Nizovtseva, E. V.

AU - Gerasimova, N. S.

AU - Studitsky, V. M.

PY - 2019/10/1

Y1 - 2019/10/1

N2 - Abstract: Long-distance interaction plays an important role in the regulation of eukaryotic genes. Chromatin structure is involved in the process, but the role of histone modifications has not been studied. In the present work, the role of acetylation Н4K16 (Н4K16-Ac) to enhancer-promoter communication (EPC) was analyzed. This modification is associated with euchromatin and is involved in the decompaction of chromatin fibers. We have shown that the effect of H4K16-Ac on EPC in vitro depends on the level of chromatin assembly. EPC in chromatin, which lacks nucleosomes at random positions on DNA, is inhibited in the presence of H4K16-Aс. At the same time, EPC in chromatin, in which nucleosomes occupy all available positions on DNA, is somewhat stimulated in the presence of H4K16-Aс.

AB - Abstract: Long-distance interaction plays an important role in the regulation of eukaryotic genes. Chromatin structure is involved in the process, but the role of histone modifications has not been studied. In the present work, the role of acetylation Н4K16 (Н4K16-Ac) to enhancer-promoter communication (EPC) was analyzed. This modification is associated with euchromatin and is involved in the decompaction of chromatin fibers. We have shown that the effect of H4K16-Ac on EPC in vitro depends on the level of chromatin assembly. EPC in chromatin, which lacks nucleosomes at random positions on DNA, is inhibited in the presence of H4K16-Aс. At the same time, EPC in chromatin, in which nucleosomes occupy all available positions on DNA, is somewhat stimulated in the presence of H4K16-Aс.

KW - acetylation

KW - chromatin

KW - enhancers

KW - histones

KW - modifications

KW - regulation

KW - transcription

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EP - 249

JO - Moscow University Biological Sciences Bulletin

JF - Moscow University Biological Sciences Bulletin

IS - 4

ER -

Effect of Acetylation of Histone H4 on Communication in Chromatin

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