Editorial Expression of Concern: A FADD-dependent innate immune mechanism in mammalian cells

The Editors would like to alert the readers to concerns raised regarding some of the microscopy images presented in this article, specifically: • Figure 1g: VSV Untreated and + Anti-IFN-α neutralising Ab images appear to overlap; • Figure 4a: Wild type –IFN, IKKβ⁺ –IFN, Fig. 4g VSV Irf3⁺ and VSV + IFN-α/β pre-treatment images appear to originate from the same sample; • Figure 4a: IKKα⁺ –IFN and Fig. 4g VSV Irf3^+/+ images appear to overlap; • Figure S1a: MOCK FADD^+/–, FADD^–/– and Fig. S1c MOCK FADD^+/– images appear to originate from the same sample; • Figure S2a: VSV Casp8^+/+ and Casp8^–/– images appear to overlap. The authors brought these issues to the attention of the Editors and have stated that the overlapping images were included by error. They have since repeated the experiments and have reproduced the results shown in these figure panels. But due to the age of the article, the authors have been unable to recover the full set of original microscopy images shown in these panels. The readers are therefore advised to interpret the aforementioned figures with caution. All authors agree to this Editorial Expression of Concern.