Dynamic Regulation of Histone Lysine Methylation by Demethylases

Yang Shi; Johnathan R. Whetstine

doi:10.1016/j.molcel.2006.12.010

Dynamic Regulation of Histone Lysine Methylation by Demethylases

Yang Shi, Johnathan R. Whetstine

Harvard University

Research output: Contribution to journal › Review article › peer-review

575 Scopus citations

Abstract

Recent studies demonstrated that histone methylation is not static but is dynamically regulated by histone methyltransferases and the newly discovered histone demethylases. This review discusses the chemical mechanisms for the known and potentially new classes of demethylases, the roles of these demethylases in chromatin and transcription, and their potential biological functions and connections to human diseases.

Original language	English
Pages (from-to)	1-14
Number of pages	14
Journal	Molecular Cell
Volume	25
Issue number	1
DOIs	https://doi.org/10.1016/j.molcel.2006.12.010
State	Published - Jan 12 2007

Keywords

Animals
Chromatin/metabolism
Histones/metabolism
Humans
Lysine/metabolism
Methylation
Oxidoreductases, N-Demethylating/chemistry
Protein Structure, Tertiary

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10.1016/j.molcel.2006.12.010

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abstract = "Recent studies demonstrated that histone methylation is not static but is dynamically regulated by histone methyltransferases and the newly discovered histone demethylases. This review discusses the chemical mechanisms for the known and potentially new classes of demethylases, the roles of these demethylases in chromatin and transcription, and their potential biological functions and connections to human diseases.",

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AB - Recent studies demonstrated that histone methylation is not static but is dynamically regulated by histone methyltransferases and the newly discovered histone demethylases. This review discusses the chemical mechanisms for the known and potentially new classes of demethylases, the roles of these demethylases in chromatin and transcription, and their potential biological functions and connections to human diseases.

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KW - Chromatin/metabolism

KW - Histones/metabolism

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KW - Lysine/metabolism

KW - Methylation

KW - Oxidoreductases, N-Demethylating/chemistry

KW - Protein Structure, Tertiary

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JO - Molecular Cell

JF - Molecular Cell

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Dynamic Regulation of Histone Lysine Methylation by Demethylases

Abstract

Keywords

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