Driving to Cancer on a Four-Lane Expressway

Lorenzo Galluzzi; Ilio Vitale

doi:10.1016/j.tig.2017.06.003

Driving to Cancer on a Four-Lane Expressway

Lorenzo Galluzzi, Ilio Vitale

Research output: Contribution to journal › Short survey › peer-review

6 Scopus citations

Abstract

Recent findings from a prospective clinical study involving multiregion whole-exome sequencing suggest that driver mutations in cancer-relevant genes including EGFR and TP53 are often clonal and precede whole-genome duplication events in early lung carcinogenesis. This paves an expressway to extensive subclonal diversification, elevated intratumoral heterogeneity, and dismal disease outcome.

Original language	English
Pages (from-to)	491-492
Number of pages	2
Journal	Trends in Genetics
Volume	33
Issue number	8
DOIs	https://doi.org/10.1016/j.tig.2017.06.003
State	Published - Aug 2017
Externally published	Yes

Keywords

aneuploidy
APOBEC
chromosomal instability
non-small cell lung carcinoma
p53
tetraploidy

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.tig.2017.06.003

Cite this

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title = "Driving to Cancer on a Four-Lane Expressway",

abstract = "Recent findings from a prospective clinical study involving multiregion whole-exome sequencing suggest that driver mutations in cancer-relevant genes including EGFR and TP53 are often clonal and precede whole-genome duplication events in early lung carcinogenesis. This paves an expressway to extensive subclonal diversification, elevated intratumoral heterogeneity, and dismal disease outcome.",

keywords = "aneuploidy, APOBEC, chromosomal instability, non-small cell lung carcinoma, p53, tetraploidy",

author = "Lorenzo Galluzzi and Ilio Vitale",

note = "Publisher Copyright: {\textcopyright} 2017 Elsevier Ltd",

year = "2017",

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doi = "10.1016/j.tig.2017.06.003",

language = "English",

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T1 - Driving to Cancer on a Four-Lane Expressway

AU - Galluzzi, Lorenzo

AU - Vitale, Ilio

PY - 2017/8

Y1 - 2017/8

N2 - Recent findings from a prospective clinical study involving multiregion whole-exome sequencing suggest that driver mutations in cancer-relevant genes including EGFR and TP53 are often clonal and precede whole-genome duplication events in early lung carcinogenesis. This paves an expressway to extensive subclonal diversification, elevated intratumoral heterogeneity, and dismal disease outcome.

AB - Recent findings from a prospective clinical study involving multiregion whole-exome sequencing suggest that driver mutations in cancer-relevant genes including EGFR and TP53 are often clonal and precede whole-genome duplication events in early lung carcinogenesis. This paves an expressway to extensive subclonal diversification, elevated intratumoral heterogeneity, and dismal disease outcome.

KW - aneuploidy

KW - APOBEC

KW - chromosomal instability

KW - non-small cell lung carcinoma

KW - p53

KW - tetraploidy

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U2 - 10.1016/j.tig.2017.06.003

DO - 10.1016/j.tig.2017.06.003

M3 - Short survey

C2 - 28668385

AN - SCOPUS:85021358886

SN - 0168-9525

VL - 33

SP - 491

EP - 492

JO - Trends in Genetics

JF - Trends in Genetics

IS - 8

ER -

Driving to Cancer on a Four-Lane Expressway

Abstract

Keywords

UN SDGs

Access to Document

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