Domain definition and target classification for CASP6

Michael Tress; Chin Hsien Tai; Guoli Wang; Iakes Ezkurdia; Gonzalo López; Alfonso Valencia; Byungkook Lee; Roland L. Dunbrack

doi:10.1002/prot.20717

Domain definition and target classification for CASP6

Michael Tress, Chin Hsien Tai, Guoli Wang, Iakes Ezkurdia, Gonzalo López, Alfonso Valencia, Byungkook Lee, Roland L. Dunbrack

Cancer Signaling and Microenvironment (CSM)

Research output: Contribution to journal › Article › peer-review

26 Scopus citations

Abstract

Assessment of structure predictions in CASP6 was based on single domains isolated from experimentally determined structures, which were categorized into comparative modeling, fold recognition, and new fold targets. Domain definitions were defined upon visual examination of the structures with the aid of automated domain-parsing programs. Domain categorization was determined by comparison of the target structures with those in the Protein Data Bank at the time each target expired and a variety of sequence and structure-based methods to determine potential homologous relationships.

Original language	English
Pages (from-to)	8-18
Number of pages	11
Journal	Proteins: Structure, Function and Bioinformatics
Volume	61 Suppl 7
Issue number	SUPPL. 7
DOIs	https://doi.org/10.1002/prot.20717
State	Published - 2005

Keywords

Amino Acid Sequence
Animals
Computational Biology/methods
Databases, Protein
Humans
Models, Molecular
Molecular Sequence Data
Protein Folding
Protein Structure, Secondary
Protein Structure, Tertiary
Proteins/chemistry
Proteomics/methods
Sequence Homology, Amino Acid

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10.1002/prot.20717

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AU - Tress, Michael

AU - Tai, Chin Hsien

AU - Wang, Guoli

AU - Ezkurdia, Iakes

AU - López, Gonzalo

AU - Valencia, Alfonso

AU - Lee, Byungkook

AU - Dunbrack, Roland L.

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KW - Molecular Sequence Data

KW - Protein Folding

KW - Protein Structure, Secondary

KW - Protein Structure, Tertiary

KW - Proteins/chemistry

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Domain definition and target classification for CASP6

Abstract

Keywords

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