Abstract
DNA damage caused by endogenous and exogenous agents represents a serious survival challenge for cells. The cell-cycle checkpoints and DNA repair mechanisms are activated to allow more time for effective repair. However, if these mechanisms fail or the damage is irreparable, then apoptosis is induced to eliminate cells carrying DNA lesions and preserve genomic integrity. This chapter discusses how DNA damage-dependent apoptosis is induced and executed.
Original language | English |
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Title of host publication | Apoptosis, Cell Signaling, and Human Diseases |
Publisher | Humana Press Inc. |
Pages | 263-272 |
Number of pages | 10 |
Volume | 2 |
ISBN (Print) | 1588296776, 9781588296771 |
DOIs | |
State | Published - 2007 |
Externally published | Yes |
Keywords
- DNA damage
- DNA repair
- apoptosis
- checkpoint
- mismatch
- p53
- p73