DNA damage-dependent apoptosis

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

1 Scopus citations

Abstract

DNA damage caused by endogenous and exogenous agents represents a serious survival challenge for cells. The cell-cycle checkpoints and DNA repair mechanisms are activated to allow more time for effective repair. However, if these mechanisms fail or the damage is irreparable, then apoptosis is induced to eliminate cells carrying DNA lesions and preserve genomic integrity. This chapter discusses how DNA damage-dependent apoptosis is induced and executed.

Original languageEnglish
Title of host publicationApoptosis, Cell Signaling, and Human Diseases
PublisherHumana Press Inc.
Pages263-272
Number of pages10
Volume2
ISBN (Print)1588296776, 9781588296771
DOIs
StatePublished - 2007
Externally publishedYes

Keywords

  • DNA damage
  • DNA repair
  • apoptosis
  • checkpoint
  • mismatch
  • p53
  • p73

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