Diverted Total Synthesis of Carolacton-Inspired Analogs Yields Three Distinct Phenotypes in Streptococcus mutans Biofilms

Amy E. Solinski, Alexander B. Koval, Richard S. Brzozowski, Kelly R. Morrison, Americo J. Fraboni, Carrie E. Carson, Anisa R. Eshraghi, Guangfeng Zhou, Robert G. Quivey, Vincent A. Voelz, Bettina A. Buttaro, William M. Wuest

Research output: Contribution to journalArticlepeer-review

27 Scopus citations

Abstract

The oral microbiome is a dynamic environment inhabited by both commensals and pathogens. Among these is Streptococcus mutans, the causative agent of dental caries, the most prevalent childhood disease. Carolacton has remarkably specific activity against S. mutans, causing acid-mediated cell death during biofilm formation; however, its complex structure limits its utility. Herein, we report the diverted total synthesis and biological evaluation of a rationally designed library of simplified analogs that unveiled three unique biofilm phenotypes further validating the role of natural product synthesis in the discovery of new biological phenomena.

Original languageEnglish
Pages (from-to)7188-7191
Number of pages4
JournalJournal of the American Chemical Society
Volume139
Issue number21
DOIs
StatePublished - May 31 2017
Externally publishedYes

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