Distant Activation of Transcription by Enhancers

O. Kulaeva; V. M. Studitsky

doi:10.1016/B978-0-12-821618-7.10051-3

Distant Activation of Transcription by Enhancers

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

Abstract

Recent genomic studies have revealed a large number of distantly-acting regulatory DNA regions activating transcription (enhancers). Typically, interactions between enhancers and their targets (promoters) involve chromatin looping directed by proteins specifically bound at the interacting DNA regions. Such dynamic regulatory chromatin loops of different size and stability form extensive and complex three-dimensional networks that largely define gene expression patterns and identity of eukaryotic cells. Misalignment of these networks results in development of numerous human diseases including cancer.

Original language	English
Title of host publication	Encyclopedia of Cell Biology
Subtitle of host publication	Volume 1-6, Second Edition
Publisher	Elsevier
Pages	617-624
Number of pages	8
Volume	1
ISBN (Electronic)	9780128216248
DOIs	https://doi.org/10.1016/B978-0-12-821618-7.10051-3
State	Published - Jan 1 2022

Keywords

Active chromatin
DNA looping
Distant activation
Enhancer
Enhancer-binding proteins
Enhancer-promoter communication
Poised chromatin
Promoter
Transcription

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/B978-0-12-821618-7.10051-3

Cite this

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AB - Recent genomic studies have revealed a large number of distantly-acting regulatory DNA regions activating transcription (enhancers). Typically, interactions between enhancers and their targets (promoters) involve chromatin looping directed by proteins specifically bound at the interacting DNA regions. Such dynamic regulatory chromatin loops of different size and stability form extensive and complex three-dimensional networks that largely define gene expression patterns and identity of eukaryotic cells. Misalignment of these networks results in development of numerous human diseases including cancer.

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KW - DNA looping

KW - Distant activation

KW - Enhancer

KW - Enhancer-binding proteins

KW - Enhancer-promoter communication

KW - Poised chromatin

KW - Promoter

KW - Transcription

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SP - 617

EP - 624

BT - Encyclopedia of Cell Biology

PB - Elsevier

ER -

Distant Activation of Transcription by Enhancers

Abstract

Keywords

UN SDGs

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