TY - JOUR
T1 - Diffuse gastric cancer
T2 - Histologic, molecular, and genetic basis of disease
AU - Iyer, Pritish
AU - Moslim, Maitham
AU - Farma, Jeffrey M.
AU - Denlinger, Crystal S.
N1 - Publisher Copyright:
© Translational Gastroenterology and Hepatology. All rights reserved.
PY - 2020/7
Y1 - 2020/7
N2 - Diffuse gastric cancer (DGC) is a distinct histopathologic and molecular disease, characterized by mutations in CDH1, RHOA, and others. In addition, DGC is associated with familial syndromes, including hereditary DGC and germline mutation in CDH1. Clinically, this subtype of gastric adenocarcinoma is associated with a poor prognosis and possible resistance to available systemic therapies. An understanding of the genetic and molecular underpinnings of DGC may help inform of its clinical behavior and aid in screening, diagnosis, and response to treatment. In this review, we will review the current histologic, molecular, and genetic landscape of DGC and its relevance to clinical practice.
AB - Diffuse gastric cancer (DGC) is a distinct histopathologic and molecular disease, characterized by mutations in CDH1, RHOA, and others. In addition, DGC is associated with familial syndromes, including hereditary DGC and germline mutation in CDH1. Clinically, this subtype of gastric adenocarcinoma is associated with a poor prognosis and possible resistance to available systemic therapies. An understanding of the genetic and molecular underpinnings of DGC may help inform of its clinical behavior and aid in screening, diagnosis, and response to treatment. In this review, we will review the current histologic, molecular, and genetic landscape of DGC and its relevance to clinical practice.
KW - Cancer
KW - Diffuse
KW - Gastric
UR - http://www.scopus.com/inward/record.url?scp=85085189941&partnerID=8YFLogxK
U2 - 10.21037/tgh.2020.01.02
DO - 10.21037/tgh.2020.01.02
M3 - Review article
AN - SCOPUS:85085189941
SN - 2224-476X
VL - 5
JO - Translational Gastroenterology and Hepatology
JF - Translational Gastroenterology and Hepatology
M1 - 52
ER -
