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Different Appearances of Esophageal Squamous Cell Carcinoma in 18 F-PSMA PET/CT Versus 18 F-FDG PET/CT

  • Department of Radiology
  • Fox Chase Cancer Center
  • Temple University Health Systems
  • Division of Nuclear Medicine

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

An 81-year-old man with a history of prostate cancer, status post radiation therapy, was referred for a prostate-specific membrane antigen (PSMA) PET/CT scan. Fluorine-18 DCF-Pyl (Pylarify) PSMA PET/CT showed focal increased radiotracer uptake at the right prostate and bilateral iliac chain metastatic lymph nodes. The same PSMA PET/CT showed focal increased radiotracer uptake at the junction of the mid to lower esophagus. 18 F-FDG PET/CT identified a large hypermetabolic esophageal mass in the mid to lower esophagus, showing a greater extent of esophageal disease than the PSMA PET/CT. An endoscopic biopsy confirmed poorly differentiated esophageal squamous cell carcinoma.

Original languageEnglish
Pages (from-to)774-777
Number of pages4
JournalClinical Nuclear Medicine
Volume50
Issue number8
DOIs
StatePublished - Aug 1 2025

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

  1. SDG 3 - Good Health and Well-being
    SDG 3 Good Health and Well-being

Keywords

  • Humans
  • Male
  • Positron Emission Tomography Computed Tomography
  • Esophageal Neoplasms/diagnostic imaging
  • Aged, 80 and over
  • Fluorodeoxyglucose F18
  • Esophageal Squamous Cell Carcinoma
  • Carcinoma, Squamous Cell/diagnostic imaging
  • Glutamate Carboxypeptidase II/metabolism
  • Antigens, Surface

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