Diet and its role in interstitial cystitis/bladder pain syndrome (IC/BPS) and comorbid conditions

Justin I. Friedlander, Barbara Shorter, Robert M. Moldwin

Research output: Contribution to journalReview articlepeer-review

94 Scopus citations


Up to 90% of patients with interstitial cystitis/bladder pain syndrome (IC/BPS) report sensitivities to a wide variety of comestibles. Pathological mechanisms suggested to be responsible for the relationship between dietary intake and symptom exacerbation include peripheral and/or central neural upregulation, bladder epithelial dysfunction, and organ 'cross-talk', amongst others. Current questionnaire-based data suggests that citrus fruits, tomatoes, vitamin C, artificial sweeteners, coffee, tea, carbonated and alcoholic beverages, and spicy foods tend to exacerbate symptoms, while calcium glycerophosphate and sodium bicarbonate tend to improve symptoms. Specific comestible sensitivities varied between patients and may have been influenced by comorbid conditions. This suggests that a controlled method to determine dietary sensitivities, such as an elimination diet, may play an important role in patient management.

Original languageEnglish
Pages (from-to)1584-1591
Number of pages8
JournalBJU International
Issue number11
StatePublished - Jun 2012


  • Cystitis, Interstitial/etiology
  • Diet
  • Humans


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