Dicentric chromosome 17 in patients with leukemia

Joseph R. Testa; Bruce C. Cohen

doi:10.1016/0165-4608(86)90148-2

Dicentric chromosome 17 in patients with leukemia

Joseph R. Testa, Bruce C. Cohen

Cancer Prevention and Control (CPC)

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

A putative isochromosome of the long arm of chromosome #17 was identified in bone marrow cells from each of six patients with leukemia. Adequate sample was available for detailed study in four patients, and in each of these four cases examination with multiple staining techniques implied that the rearrangement is a dicentric chromosome, dic(17)(p11.2). An asymmetry of constriction at the two centromeric regions suggested that one centromere was inactive. The data presented here suggest that many of the presumed i(17q) markers observed in leukemia may actually represent dicentric rearrangements.

Original language	English
Pages (from-to)	47-52
Number of pages	6
Journal	Cancer Genetics and Cytogenetics
Volume	23
Issue number	1
DOIs	https://doi.org/10.1016/0165-4608(86)90148-2
State	Published - Sep 1986

Keywords

Centromere/ultrastructure
Chromosome Aberrations
Chromosome Banding
Chromosomes, Human, 16-18
Chromosomes/ultrastructure
Humans
Karyotyping
Leukemia, Lymphoid/genetics
Leukemia, Myeloid/genetics
Leukemia/genetics

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title = "Dicentric chromosome 17 in patients with leukemia",

abstract = "A putative isochromosome of the long arm of chromosome #17 was identified in bone marrow cells from each of six patients with leukemia. Adequate sample was available for detailed study in four patients, and in each of these four cases examination with multiple staining techniques implied that the rearrangement is a dicentric chromosome, dic(17)(p11.2). An asymmetry of constriction at the two centromeric regions suggested that one centromere was inactive. The data presented here suggest that many of the presumed i(17q) markers observed in leukemia may actually represent dicentric rearrangements.",

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T1 - Dicentric chromosome 17 in patients with leukemia

AU - Testa, Joseph R.

AU - Cohen, Bruce C.

PY - 1986/9

Y1 - 1986/9

N2 - A putative isochromosome of the long arm of chromosome #17 was identified in bone marrow cells from each of six patients with leukemia. Adequate sample was available for detailed study in four patients, and in each of these four cases examination with multiple staining techniques implied that the rearrangement is a dicentric chromosome, dic(17)(p11.2). An asymmetry of constriction at the two centromeric regions suggested that one centromere was inactive. The data presented here suggest that many of the presumed i(17q) markers observed in leukemia may actually represent dicentric rearrangements.

AB - A putative isochromosome of the long arm of chromosome #17 was identified in bone marrow cells from each of six patients with leukemia. Adequate sample was available for detailed study in four patients, and in each of these four cases examination with multiple staining techniques implied that the rearrangement is a dicentric chromosome, dic(17)(p11.2). An asymmetry of constriction at the two centromeric regions suggested that one centromere was inactive. The data presented here suggest that many of the presumed i(17q) markers observed in leukemia may actually represent dicentric rearrangements.

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KW - Chromosome Aberrations

KW - Chromosome Banding

KW - Chromosomes, Human, 16-18

KW - Chromosomes/ultrastructure

KW - Humans

KW - Karyotyping

KW - Leukemia, Lymphoid/genetics

KW - Leukemia, Myeloid/genetics

KW - Leukemia/genetics

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Dicentric chromosome 17 in patients with leukemia

Abstract

Keywords

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