Abstract
Numerous parallelisms exist between development and cancer. In this article, I review some of the founding ideas linking development and cancer, and highlight clinical conditions exhibiting features of both developmental derangement and cancer predisposition, including cohesinopathies, rasopathies, phakomatoses, Proteus syndrome and other overgrowth disorders, recessive chromosome breakage syndromes, and dominant hereditary cancer syndromes. I suggest that these disorders encompass a continuous spectrum spanning clinical genetics and clinical oncology, and derive some general implications that might be useful in the future for the treatment of these diseases.
| Original language | English |
|---|---|
| Pages (from-to) | 2788-2796 |
| Number of pages | 9 |
| Journal | American Journal of Medical Genetics, Part A |
| Volume | 161 |
| Issue number | 11 |
| DOIs | |
| State | Published - Nov 2013 |
UN SDGs
This output contributes to the following UN Sustainable Development Goals (SDGs)
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SDG 3 Good Health and Well-being
Keywords
- Developmental Disabilities/complications
- Epigenesis, Genetic
- Genetic Predisposition to Disease
- Humans
- Neoplasms/complications
- Phenotype
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