Developmental disease and cancer: Biological and clinical overlaps

Alfonso Bellacosa

doi:10.1002/ajmg.a.36267

Developmental disease and cancer: Biological and clinical overlaps

Alfonso Bellacosa

Research output: Contribution to journal › Article › peer-review

27 Scopus citations

Abstract

Numerous parallelisms exist between development and cancer. In this article, I review some of the founding ideas linking development and cancer, and highlight clinical conditions exhibiting features of both developmental derangement and cancer predisposition, including cohesinopathies, rasopathies, phakomatoses, Proteus syndrome and other overgrowth disorders, recessive chromosome breakage syndromes, and dominant hereditary cancer syndromes. I suggest that these disorders encompass a continuous spectrum spanning clinical genetics and clinical oncology, and derive some general implications that might be useful in the future for the treatment of these diseases.

Original language	English
Pages (from-to)	2788-2796
Number of pages	9
Journal	American Journal of Medical Genetics, Part A
Volume	161
Issue number	11
DOIs	https://doi.org/10.1002/ajmg.a.36267
State	Published - Nov 2013

Keywords

Developmental Disabilities/complications
Epigenesis, Genetic
Genetic Predisposition to Disease
Humans
Neoplasms/complications
Phenotype

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1002/ajmg.a.36267

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abstract = "Numerous parallelisms exist between development and cancer. In this article, I review some of the founding ideas linking development and cancer, and highlight clinical conditions exhibiting features of both developmental derangement and cancer predisposition, including cohesinopathies, rasopathies, phakomatoses, Proteus syndrome and other overgrowth disorders, recessive chromosome breakage syndromes, and dominant hereditary cancer syndromes. I suggest that these disorders encompass a continuous spectrum spanning clinical genetics and clinical oncology, and derive some general implications that might be useful in the future for the treatment of these diseases.",

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KW - Neoplasms/complications

KW - Phenotype

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Developmental disease and cancer: Biological and clinical overlaps

Abstract

Keywords

UN SDGs

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