Abstract
While the functions of αδ T cells in host resistance to pathogen infection are understood in far more detail than those of γδ lineage T cells, γδ T cells perform critical, essential functions during immune responses that cannot be compensated by αδ T cells. Accordingly, it is essential to understand how the development of γδ T cells is controlled so that their generation and function might be manipulated in future for therapeutic benefit. This introductory chapter will cover the basic processes that underlie γδ T cell development in the thymus, as well as the current understanding of how they are controlled.
Original language | English |
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Pages (from-to) | 23-32 |
Number of pages | 10 |
Journal | Methods in Molecular Biology |
Volume | 1323 |
DOIs | |
State | Published - 2016 |
Keywords
- Effector fate
- Gamma-delta T cells
- Gamma-delta TCR
- Lineage commitment
- V gamma elements