Development of γδ T Cells, the Special-Force Soldiers of the Immune System

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Abstract

While the functions of αδ T cells in host resistance to pathogen infection are understood in far more detail than those of γδ lineage T cells, γδ T cells perform critical, essential functions during immune responses that cannot be compensated by αδ T cells. Accordingly, it is essential to understand how the development of γδ T cells is controlled so that their generation and function might be manipulated in future for therapeutic benefit. This introductory chapter will cover the basic processes that underlie γδ T cell development in the thymus, as well as the current understanding of how they are controlled.

Original languageEnglish
Pages (from-to)23-32
Number of pages10
JournalMethods in Molecular Biology
Volume1323
DOIs
StatePublished - 2016

Keywords

  • Effector fate
  • Gamma-delta T cells
  • Gamma-delta TCR
  • Lineage commitment
  • V gamma elements

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