Development of γδ T cells, the special-force soldiers of the immune system

David L. Wiest

doi:10.1007/978-1-4939-2809-5_2

Development of γδ T cells, the special-force soldiers of the immune system

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

Abstract

While the functions of αβ T cells in host resistance to pathogen infection are understood in far more detail than those of γδ lineage T cells, γδ T cells perform critical, essential functions during immune responses that cannot be compensated by αβ T cells. Accordingly, it is essential to understand how the development of γδ T cells is controlled so that their generation and function might be manipulated in future for therapeutic benefit. This introductory chapter will cover the basic processes that underlie γδ T cell development in the thymus, as well as the current understanding of how they are controlled.

Original language	English
Title of host publication	T-Cell Development
Subtitle of host publication	Methods and Protocols
Publisher	Springer New York
Pages	23-32
Number of pages	10
ISBN (Electronic)	9781493928095
ISBN (Print)	9781493928088
DOIs	https://doi.org/10.1007/978-1-4939-2809-5_2
State	Published - Aug 20 2015

Keywords

Effector fate
Gamma-delta T cells
Gamma-delta TCR
Lineage commitment
V gamma elements

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10.1007/978-1-4939-2809-5_2

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AB - While the functions of αβ T cells in host resistance to pathogen infection are understood in far more detail than those of γδ lineage T cells, γδ T cells perform critical, essential functions during immune responses that cannot be compensated by αβ T cells. Accordingly, it is essential to understand how the development of γδ T cells is controlled so that their generation and function might be manipulated in future for therapeutic benefit. This introductory chapter will cover the basic processes that underlie γδ T cell development in the thymus, as well as the current understanding of how they are controlled.

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PB - Springer New York

ER -

Development of γδ T cells, the special-force soldiers of the immune system

Abstract

Keywords

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