Development of γδ T Cells: Soldiers on the Front Lines of Immune Battles

Alejandra V Contreras; David L Wiest

doi:10.1007/978-1-0716-2740-2_4

Development of γδ T Cells: Soldiers on the Front Lines of Immune Battles

Alejandra V Contreras, David L Wiest

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

While the functions of αβ T cells in host resistance to pathogen infection are understood in far more detail than those of γδ lineage T cells, γδ T cells perform critical, essential functions during immune responses that cannot be compensated for by αβ T cells. Accordingly, it is critical to understand how the development of γδ T cells is controlled so that their generation and function might be manipulated in future for therapeutic benefit. This introductory chapter will focus primarily on the basic processes that underlie γδ T cell development in the thymus, as well as the current understanding of how they are controlled.

Original language	English
Pages (from-to)	71-88
Number of pages	18
Journal	Methods in molecular biology (Clifton, N.J.)
Volume	2580
DOIs	https://doi.org/10.1007/978-1-0716-2740-2_4
State	Published - 2023

Keywords

Humans
Receptors, Antigen, T-Cell, gamma-delta
Cell Lineage
Cell Differentiation
Military Personnel
T-Lymphocytes
Receptors, Antigen, T-Cell, alpha-beta
T-Lymphocyte Subsets

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10.1007/978-1-0716-2740-2_4

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title = "Development of γδ T Cells: Soldiers on the Front Lines of Immune Battles",

abstract = "While the functions of αβ T cells in host resistance to pathogen infection are understood in far more detail than those of γδ lineage T cells, γδ T cells perform critical, essential functions during immune responses that cannot be compensated for by αβ T cells. Accordingly, it is critical to understand how the development of γδ T cells is controlled so that their generation and function might be manipulated in future for therapeutic benefit. This introductory chapter will focus primarily on the basic processes that underlie γδ T cell development in the thymus, as well as the current understanding of how they are controlled.",

keywords = "Humans, Receptors, Antigen, T-Cell, gamma-delta, Cell Lineage, Cell Differentiation, Military Personnel, T-Lymphocytes, Receptors, Antigen, T-Cell, alpha-beta, T-Lymphocyte Subsets",

author = "Contreras, \{Alejandra V\} and Wiest, \{David L\}",

note = "{\textcopyright} 2023. This is a U.S. government work and not under copyright protection in the U.S.; foreign copyright protection may apply.",

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doi = "10.1007/978-1-0716-2740-2\_4",

language = "English",

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pages = "71--88",

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T2 - Soldiers on the Front Lines of Immune Battles

AU - Contreras, Alejandra V

AU - Wiest, David L

PY - 2023

Y1 - 2023

N2 - While the functions of αβ T cells in host resistance to pathogen infection are understood in far more detail than those of γδ lineage T cells, γδ T cells perform critical, essential functions during immune responses that cannot be compensated for by αβ T cells. Accordingly, it is critical to understand how the development of γδ T cells is controlled so that their generation and function might be manipulated in future for therapeutic benefit. This introductory chapter will focus primarily on the basic processes that underlie γδ T cell development in the thymus, as well as the current understanding of how they are controlled.

AB - While the functions of αβ T cells in host resistance to pathogen infection are understood in far more detail than those of γδ lineage T cells, γδ T cells perform critical, essential functions during immune responses that cannot be compensated for by αβ T cells. Accordingly, it is critical to understand how the development of γδ T cells is controlled so that their generation and function might be manipulated in future for therapeutic benefit. This introductory chapter will focus primarily on the basic processes that underlie γδ T cell development in the thymus, as well as the current understanding of how they are controlled.

KW - Humans

KW - Receptors, Antigen, T-Cell, gamma-delta

KW - Cell Lineage

KW - Cell Differentiation

KW - Military Personnel

KW - T-Lymphocytes

KW - Receptors, Antigen, T-Cell, alpha-beta

KW - T-Lymphocyte Subsets

UR - https://www.scopus.com/pages/publications/85141936979

U2 - 10.1007/978-1-0716-2740-2_4

DO - 10.1007/978-1-0716-2740-2_4

M3 - Article

C2 - 36374451

SN - 1064-3745

VL - 2580

SP - 71

EP - 88

JO - Methods in molecular biology (Clifton, N.J.)

JF - Methods in molecular biology (Clifton, N.J.)

ER -

Development of γδ T Cells: Soldiers on the Front Lines of Immune Battles

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