Delayed hemorrhage after cervical conization unmasking severe factor XI deficiency

Sarah H. Kim, Sindhu K. Srinivas, Stephen C. Rubin, Louis J. Freedman, Heidi J. Gray

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

BACKGROUND:: Factor XI deficiency, a rare bleeding disorder found most commonly in patients of Ashkenazi Jewish background, may be present in patients with a history of abnormal bleeding after elective surgery. CASE:: A patient of Ashkenazi Jewish descent presented 12 days after cervical conization for adenocarcinoma in situ with severe vaginal bleeding requiring multiple transfusions and uterine artery embolization. After a thorough workup, a severe factor XI deficiency was found. The patient ultimately required modified radical hysterectomy for treatment of early cervical cancer. With appropriate perioperative management, the patient underwent abdominal surgery without further bleeding complications. CONCLUSION:: Factor XI deficiency can present with severe bleeding episodes after elective surgery. Adequate preoperative assessment and perioperative management are necessary to prevent bleeding complications in these patients.

Original languageEnglish
Pages (from-to)1189-1192
Number of pages4
JournalObstetrics and Gynecology
Volume104
Issue number5 PART 2
DOIs
StatePublished - Nov 2004

Keywords

  • Adenocarcinoma/diagnosis
  • Adult
  • Blood Transfusion
  • Combined Modality Therapy
  • Conization/adverse effects
  • Diagnosis, Differential
  • Embolization, Therapeutic
  • Factor XI Deficiency/diagnosis
  • Female
  • Follow-Up Studies
  • Humans
  • Hysterectomy/methods
  • Postoperative Hemorrhage/diagnosis
  • Risk Assessment
  • Severity of Illness Index
  • Time Factors
  • Treatment Outcome
  • Uterine Cervical Neoplasms/diagnosis

Fingerprint

Dive into the research topics of 'Delayed hemorrhage after cervical conization unmasking severe factor XI deficiency'. Together they form a unique fingerprint.

Cite this