Defective Autophagy Initiates Malignant Transformation

Lorenzo Galluzzi; José Manuel Bravo-San Pedro; Guido Kroemer

doi:10.1016/j.molcel.2016.05.001

Defective Autophagy Initiates Malignant Transformation

Lorenzo Galluzzi, José Manuel Bravo-San Pedro, Guido Kroemer

Research output: Contribution to journal › Short survey › peer-review

24 Scopus citations

Abstract

In this issue of Molecular Cell, Park et al. (2016) elegantly demonstrate that a partial defect in autophagy supports malignant transformation as it favors the production of genotoxic reactive oxygen species by mitochondria. In this issue of Molecular Cell, Park et al. (2016) elegantly demonstrate that a partial defect in autophagy supports malignant transformation as it favors the production of genotoxic reactive oxygen species by mitochondria.

Original language	English
Pages (from-to)	473-474
Number of pages	2
Journal	Molecular Cell
Volume	62
Issue number	4
DOIs	https://doi.org/10.1016/j.molcel.2016.05.001
State	Published - May 19 2016
Externally published	Yes

Keywords

Alternative splicing
Autophagic flux
Mutational rate
Myelodysplastic syndrome
Regulated cell death
U2AF1

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10.1016/j.molcel.2016.05.001

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title = "Defective Autophagy Initiates Malignant Transformation",

abstract = "In this issue of Molecular Cell, Park et al. (2016) elegantly demonstrate that a partial defect in autophagy supports malignant transformation as it favors the production of genotoxic reactive oxygen species by mitochondria. In this issue of Molecular Cell, Park et al. (2016) elegantly demonstrate that a partial defect in autophagy supports malignant transformation as it favors the production of genotoxic reactive oxygen species by mitochondria.",

keywords = "Alternative splicing, Autophagic flux, Mutational rate, Myelodysplastic syndrome, Regulated cell death, U2AF1",

author = "Lorenzo Galluzzi and {Bravo-San Pedro}, {Jos{\'e} Manuel} and Guido Kroemer",

note = "Publisher Copyright: {\textcopyright} 2016 Elsevier Inc.",

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T1 - Defective Autophagy Initiates Malignant Transformation

AU - Galluzzi, Lorenzo

AU - Bravo-San Pedro, José Manuel

AU - Kroemer, Guido

PY - 2016/5/19

Y1 - 2016/5/19

N2 - In this issue of Molecular Cell, Park et al. (2016) elegantly demonstrate that a partial defect in autophagy supports malignant transformation as it favors the production of genotoxic reactive oxygen species by mitochondria. In this issue of Molecular Cell, Park et al. (2016) elegantly demonstrate that a partial defect in autophagy supports malignant transformation as it favors the production of genotoxic reactive oxygen species by mitochondria.

AB - In this issue of Molecular Cell, Park et al. (2016) elegantly demonstrate that a partial defect in autophagy supports malignant transformation as it favors the production of genotoxic reactive oxygen species by mitochondria. In this issue of Molecular Cell, Park et al. (2016) elegantly demonstrate that a partial defect in autophagy supports malignant transformation as it favors the production of genotoxic reactive oxygen species by mitochondria.

KW - Alternative splicing

KW - Autophagic flux

KW - Mutational rate

KW - Myelodysplastic syndrome

KW - Regulated cell death

KW - U2AF1

UR - http://www.scopus.com/inward/record.url?scp=84969132760&partnerID=8YFLogxK

U2 - 10.1016/j.molcel.2016.05.001

DO - 10.1016/j.molcel.2016.05.001

M3 - Short survey

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SN - 1097-2765

VL - 62

SP - 473

EP - 474

JO - Molecular Cell

JF - Molecular Cell

IS - 4

ER -

Defective Autophagy Initiates Malignant Transformation

Abstract

Keywords

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