TY - JOUR
T1 - Cytomegalovirus Infection of the Colon
T2 - A Possible Role in Exacerbations of Inflammatory Bowel Disease
AU - Berk, Theodore
AU - Gordon, Susan J.
AU - Choi, Hong Y.
AU - Cooper, Harry S.
PY - 1985/5
Y1 - 1985/5
N2 - An exacerbation of idiopathic inflammatory bowel disease associated with the appearance of cytomegalovirus nuclear inclusion bodies in the colon was observed in two patients. In one, improvement in the colitis after withdrawal of corticosteroids suggested cytomegalovirus as the cause of the exacerbation. A review of the 16 reported cases of inflammatory bowel disease with cytomegalovirus superinfection of the colon indicates a high mortality rate (seven of 16), a frequent association with toxic dilatation of the colon, and a clinical course sufficiently severe to require colectomy in 10 of 16 patients. For exacerbations of inflammatory bowel disease associated with evidence of cytomegalovirus infection of the colon which are refractory to medical management withdrawal of corticosteroids and other immunosuppressive therapy should be considered. If necessary, early colectomy may be an appropriate alternative.
AB - An exacerbation of idiopathic inflammatory bowel disease associated with the appearance of cytomegalovirus nuclear inclusion bodies in the colon was observed in two patients. In one, improvement in the colitis after withdrawal of corticosteroids suggested cytomegalovirus as the cause of the exacerbation. A review of the 16 reported cases of inflammatory bowel disease with cytomegalovirus superinfection of the colon indicates a high mortality rate (seven of 16), a frequent association with toxic dilatation of the colon, and a clinical course sufficiently severe to require colectomy in 10 of 16 patients. For exacerbations of inflammatory bowel disease associated with evidence of cytomegalovirus infection of the colon which are refractory to medical management withdrawal of corticosteroids and other immunosuppressive therapy should be considered. If necessary, early colectomy may be an appropriate alternative.
KW - Adolescent
KW - Cell Nucleus/ultrastructure
KW - Colitis/drug therapy
KW - Cytomegalovirus Infections/complications
KW - Cytomegalovirus/ultrastructure
KW - Female
KW - Humans
KW - Inclusion Bodies/ultrastructure
KW - Intestinal Mucosa/drug effects
KW - Male
KW - Middle Aged
KW - Prednisone/therapeutic use
KW - Sulfasalazine/therapeutic use
UR - http://www.scopus.com/inward/record.url?scp=0021814724&partnerID=8YFLogxK
UR - https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=purepublist2023&SrcAuth=WosAPI&KeyUT=WOS:A1985AHN2600011&DestLinkType=FullRecord&DestApp=WOS
U2 - 10.1111/j.1572-0241.1985.tb02117.x
DO - 10.1111/j.1572-0241.1985.tb02117.x
M3 - Article
C2 - 2859801
SN - 0002-9270
VL - 80
SP - 355
EP - 360
JO - American Journal of Gastroenterology
JF - American Journal of Gastroenterology
IS - 5
ER -