Cytology of grade 1 papillary transitional cell carcinoma. A comparison of cytologic, architectural and morphometric criteria in cystoscopically obtained urine: A comparison of cytologic, architectural and morphometric criteria in cystoscopically obtained urine

A A Renshaw, D Nappi, D S Weinberg

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62 Scopus citations

Abstract

OBJECTIVE: To assess the diagnostic criteria for grade 1 papillary transitional cell carcinoma (TCC) in cystoscopically obtained urine.

STUDY DESIGN: We compared the sensitivity, specificity and positive predictive value of cytologic, architectural and morphometric (primarily architectural) criteria in 177 specimens with corresponding biopsy follow-up.

RESULTS: Sensitivities ranged from 22% to 44%, specificities from 69% to 85% and positive predictive values from 59% to 66%.

CONCLUSION: The currently described cytologic, architectural and morphometric criteria are inadequate for the identification of grade 1 papillary TCC, and the cytologic diagnosis of grade 1 papillary TCC in cystoscopically obtained urine remains unreliable.

Original languageEnglish
Pages (from-to)676-682
Number of pages7
JournalActa Cytologica
Volume40
Issue number4
DOIs
StatePublished - 1996

Keywords

  • Biopsy
  • Carcinoma, Transitional Cell/pathology
  • Coloring Agents
  • Diagnosis, Differential
  • Female
  • Humans
  • Predictive Value of Tests
  • Sensitivity and Specificity
  • Urinary Bladder Neoplasms/pathology
  • Urine/cytology

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