Cytogenetics and molecular genetics of lung cancer

Yasuhiro Mitsuuchi; Joseph R. Testa

doi:10.1002/ajmg.10692

Cytogenetics and molecular genetics of lung cancer

Yasuhiro Mitsuuchi, Joseph R. Testa

Cancer Prevention and Control (CPC)

Research output: Contribution to journal › Article › peer-review

56 Scopus citations

Abstract

The development and progression of lung cancer is a multistep process characterized by the accumulation of numerous genetic and epigenetic alterations, some of which occur early in the course of disease. In this review, we summarize cytogenetic imbalances and molecular genetic/epigenetic changes seen in human small-cell and non-smallcell lung cancer. Alterations of tumor suppressor genes and oncogenes leading to perturbations of key cell-regulatory and growth-control pathways are highlighted. The translational implications of molecular biomarkers for risk assessment, early detection, and monitoring of chemoprevention trials are discussed.

Original language	English
Pages (from-to)	183-188
Number of pages	6
Journal	American Journal of Medical Genetics, Part C: Seminars in Medical Genetics
Volume	115
Issue number	3
DOIs	https://doi.org/10.1002/ajmg.10692
State	Published - Oct 30 2002

Keywords

Cytogenetic imbalances
Genetic/epigenetic changes
Lung cancer
Molecular biomarkers
Tumor suppressor genes, oncogenes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1002/ajmg.10692

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Cytogenetics and molecular genetics of lung cancer

Abstract

Keywords

UN SDGs

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