TY - JOUR
T1 - CYP1A1, GSTM1, and GSTT1 polymorphisms, smoking, and lung cancer risk in a pooled analysis among Asian populations
AU - Lee, Kyoung Mu
AU - Kang, Daehee
AU - Clapper, Margie L.
AU - Ingelman-Sundberg, Magnus
AU - Ono-Kihara, Masko
AU - Kiyohara, Chikako
AU - Min, Shen
AU - Lan, Qing
AU - Le Marchand, Loic
AU - Lin, Pinpin
AU - Li Lung, Maria
AU - Pinarbasi, Hatice
AU - Pisani, Paola
AU - Srivatanakul, Petcharin
AU - Seow, Adeline
AU - Sugimura, Haruhiko
AU - Tokudome, Shinkan
AU - Yokota, Jun
AU - Taioli, Emanuela
PY - 2008/5
Y1 - 2008/5
N2 - To evaluate the roles of CYP1A1 polymorphisms [Ile462Val and T6235C (MspI)] and deletion of GSTM1 and and GSTT1 in lung cancer development in Asian populations, a pooled analysis was conducted on 13 existing studies included in Genetic Susceptibility to Environmental Carcinogenesis database. This pooled analysis included 1,971 cases and 2,130 controls. Lung cancer riskwas estimated as odds ratios (OR) and 95% confidence intervals (95% CI) using unconditional logistic regression model adjusting for age, sex, and pack-year. The CYP1A1 6235C variant was associated with squamous cell lung cancer (TC versus TT: OR, 1.42; 95% CI, 0.96-2.09; CC versus TT: OR, 1.97; 95% CI, 1.26-3.07; Ptrend = 0.003). In haplotype analysis, 462Val-6235T and Ile-C haplotypes were associated with lung cancer risk with reference to the Ile-T haplotype (OR, 3.41; 95% CI, 1.78-6.53 and OR, 1.39; 95% CI, 1.12-1.71, respectively). The GSTM1-null genotype increased squamous cell lung cancer risk(OR, 1.36; 95% CI, 1.05-1.77). When the interaction was evaluated with smoking, increasing trend of lung cancer riskas pack-year increased was stronger among those with the CYP1A1 6235 TC/CC genotype compared with those with TT genotype (Pinteraction = 0.001) and with the GSTM1-null genotype compared with the present type (P interaction = 0.08, when no genotype effect with no exposure was assumed). These results suggest that genetic polymorphisms in CYP1A1 and GSTM1 are associated with lung cancer riskin Asian populations. However, further investigation is warranted considering the relatively small sample size when subgroup analyses were done and the lack of environmental exposure data other than smoking.
AB - To evaluate the roles of CYP1A1 polymorphisms [Ile462Val and T6235C (MspI)] and deletion of GSTM1 and and GSTT1 in lung cancer development in Asian populations, a pooled analysis was conducted on 13 existing studies included in Genetic Susceptibility to Environmental Carcinogenesis database. This pooled analysis included 1,971 cases and 2,130 controls. Lung cancer riskwas estimated as odds ratios (OR) and 95% confidence intervals (95% CI) using unconditional logistic regression model adjusting for age, sex, and pack-year. The CYP1A1 6235C variant was associated with squamous cell lung cancer (TC versus TT: OR, 1.42; 95% CI, 0.96-2.09; CC versus TT: OR, 1.97; 95% CI, 1.26-3.07; Ptrend = 0.003). In haplotype analysis, 462Val-6235T and Ile-C haplotypes were associated with lung cancer risk with reference to the Ile-T haplotype (OR, 3.41; 95% CI, 1.78-6.53 and OR, 1.39; 95% CI, 1.12-1.71, respectively). The GSTM1-null genotype increased squamous cell lung cancer risk(OR, 1.36; 95% CI, 1.05-1.77). When the interaction was evaluated with smoking, increasing trend of lung cancer riskas pack-year increased was stronger among those with the CYP1A1 6235 TC/CC genotype compared with those with TT genotype (Pinteraction = 0.001) and with the GSTM1-null genotype compared with the present type (P interaction = 0.08, when no genotype effect with no exposure was assumed). These results suggest that genetic polymorphisms in CYP1A1 and GSTM1 are associated with lung cancer riskin Asian populations. However, further investigation is warranted considering the relatively small sample size when subgroup analyses were done and the lack of environmental exposure data other than smoking.
KW - Aged
KW - Aged, 80 and over
KW - Asian People/genetics
KW - Chi-Square Distribution
KW - Cytochrome P-450 CYP1A1
KW - Female
KW - Genetic Predisposition to Disease
KW - Genotype
KW - Glutathione Transferase/genetics
KW - Haplotypes
KW - Humans
KW - Logistic Models
KW - Lung Neoplasms/enzymology
KW - Male
KW - Middle Aged
KW - Polymorphism, Genetic/genetics
KW - Risk
KW - Smoking/adverse effects
UR - http://www.scopus.com/inward/record.url?scp=52649148138&partnerID=8YFLogxK
UR - https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=purepublist2023&SrcAuth=WosAPI&KeyUT=WOS:000256012800016&DestLinkType=FullRecord&DestApp=WOS
U2 - 10.1158/1055-9965.EPI-07-2786
DO - 10.1158/1055-9965.EPI-07-2786
M3 - Article
C2 - 18463401
SN - 1055-9965
VL - 17
SP - 1120
EP - 1126
JO - Cancer Epidemiology Biomarkers and Prevention
JF - Cancer Epidemiology Biomarkers and Prevention
IS - 5
ER -