CYLD and HCC: When Being Too Sensitive to Your Dirty Neighbors Results in Self-Destruction

Joan Font-Burgada, Ekihiro Seki, Michael Karin

Research output: Contribution to journalShort surveypeer-review

7 Scopus citations

Abstract

Hepatocellular carcinoma is the outcome of ongoing cycles of cell death and regeneration in chronic liver disease. In this issue of Cancer Cell, Nikolaou et al. show that the deubiquitinating enzyme CYLD is critical for controlling the balance between hepatocyte loss, regeneration, and malignant progression.

Original languageEnglish
Pages (from-to)711-712
Number of pages2
JournalCancer Cell
Volume21
Issue number6
DOIs
StatePublished - Jun 12 2012

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