TY - JOUR
T1 - Cutaneous CD56+ large T-cell lymphoma associated with high serum concentration of IL-2
AU - Wasik, Mariusz A.
AU - Sackstein, Robert
AU - Novick, Daniela
AU - Butmarc, Janet R.
AU - Zhang, Qian
AU - Vonderheid, Eric C.
AU - Kadin, Marshall E.
PY - 1996
Y1 - 1996
N2 - We report the case of a patient with a clinically aggressive large cell lymphoma (LCL) which expressed several T-lymphocyte markers and, in addition, CD56 and, to a lesser degree, CD68 antigens. A marked increase in serum concentration of interleukin (IL)-2 was found (490 and 167 pg/0.1 mL in two serum samples collected 6 months apart). This increase in IL-2 appeared unique to this lymphoma because serum concentration of IL-2 was not increased in any of the cases of various types of cutaneous lymphoproliferative disorders tested: mycosis fungoides-related cutaneous T-cell lymphoma (CTCL: 28 patients), granulomatous slack-skin syndrome (GS-SS: 1 patient), anaplastic large cell lymphoma (ALCL: 2 patients), subcutaneous gamma/delta T-cell lymphoma (γ/δ-TCL: 1 patient), adult-type leukemia/lymphoma (ATLL: 1 patient), and lymphomatoid papulosis (LyP: 4 patients). Furthermore, the increase in IL-2 serum concentration appeared selective in this CD56+ large- cell lymphoma-hearing patient, because concentration of none of the five other cytokines tested (IL-4, IL-6, IFNγ, GM-CSF, and TNFα) was increased. In contrast, soluble receptors for IL-2 and two of the other cytokines (IL- 6, and TNFα) were markedly increased not only in this patient, but also in most patients with the other cutaneous lymphoproliferative disorders that we examined except for lymphomatoid papulosis. These data indicate that increased IL-2 serum concentration may help to diagnose a unique type of cutaneous CD56(+) large (T-) cell lymphoma and suggest that IL-2 may play a role of an autocrine growth factor for this lymphoma.
AB - We report the case of a patient with a clinically aggressive large cell lymphoma (LCL) which expressed several T-lymphocyte markers and, in addition, CD56 and, to a lesser degree, CD68 antigens. A marked increase in serum concentration of interleukin (IL)-2 was found (490 and 167 pg/0.1 mL in two serum samples collected 6 months apart). This increase in IL-2 appeared unique to this lymphoma because serum concentration of IL-2 was not increased in any of the cases of various types of cutaneous lymphoproliferative disorders tested: mycosis fungoides-related cutaneous T-cell lymphoma (CTCL: 28 patients), granulomatous slack-skin syndrome (GS-SS: 1 patient), anaplastic large cell lymphoma (ALCL: 2 patients), subcutaneous gamma/delta T-cell lymphoma (γ/δ-TCL: 1 patient), adult-type leukemia/lymphoma (ATLL: 1 patient), and lymphomatoid papulosis (LyP: 4 patients). Furthermore, the increase in IL-2 serum concentration appeared selective in this CD56+ large- cell lymphoma-hearing patient, because concentration of none of the five other cytokines tested (IL-4, IL-6, IFNγ, GM-CSF, and TNFα) was increased. In contrast, soluble receptors for IL-2 and two of the other cytokines (IL- 6, and TNFα) were markedly increased not only in this patient, but also in most patients with the other cutaneous lymphoproliferative disorders that we examined except for lymphomatoid papulosis. These data indicate that increased IL-2 serum concentration may help to diagnose a unique type of cutaneous CD56(+) large (T-) cell lymphoma and suggest that IL-2 may play a role of an autocrine growth factor for this lymphoma.
KW - Aged
KW - CD56 Antigen/metabolism
KW - Cytokines/blood
KW - Humans
KW - Immunohistochemistry
KW - Interleukin-2/blood
KW - Lymphoma, Large B-Cell, Diffuse/diagnosis
KW - Lymphoma, T-Cell, Cutaneous/diagnosis
KW - Male
KW - Phenotype
KW - Receptors, Cytokine/metabolism
KW - Skin Neoplasms/diagnosis
UR - http://www.scopus.com/inward/record.url?scp=0030001151&partnerID=8YFLogxK
U2 - 10.1016/S0046-8177(96)90408-6
DO - 10.1016/S0046-8177(96)90408-6
M3 - Article
C2 - 8698322
AN - SCOPUS:0030001151
SN - 0046-8177
VL - 27
SP - 738
EP - 744
JO - Human Pathology
JF - Human Pathology
IS - 7
ER -